MolNFT v1 · #149867 · protein
Cryo-EM structure of the human neutral amino acid transporter ASCT2
6GCT · Neutral amino acid transporter B(0): “Cryo-EM structure of the human neutral amino acid transporter ASCT2”. Electron microscopy, 1 ligand (GLN), 20 pockets (best druggability 0.87). MolNFT v1 #149867 on GenesisL1: 3D structure…
- PDB
- 6GCT
- Type
- protein
- Length
- 1,296 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Neutral amino acid transporter B(0)
- UniProt
- Q15758
- Ligands
- GLN
- Pockets
- 20 · best druggability 0.87
Structure
electron microscopy · 1 distinct chain · 66% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Neutral amino acid transporter B(0) | protein | 432 | 66% helix, 3% strand | Q15758 |
Ligands and binding sites
- GLN · Glutamine · ligand · 3 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1086 | 0.87 | 0.87 | 55 | empty |
| 2 | 61 | 0.73 | 0.99 | 21 | GLN |
| 3 | 660 | 0.73 | 0.79 | 79 | empty |
| 4 | 661 | 0.72 | 0.79 | 76 | empty |
| 5 | 735 | 0.72 | 0.78 | 80 | empty |
Interfaces
3 interfaces between chains.
- A–C · 1405 Ų buried · 14 hydrogen bonds · protein-protein
- B–C · 1388 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 1374 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 6GCT · cryo-EM structure of the human neutral amino acid transporter ASCT2 · the same entry in another collection · chain B against B, TM-score 1.00
- Q15758 · AlphaFold monomer V2.0 prediction for neutral amino acid transporter B(0) (Q15758) · a predicted model of the same protein · chain C against A, TM-score 0.64
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15758
- Elsewhere: RCSB PDB 6GCT · PDBe 6GCT · UniProt Q15758
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.