UniProt Q09427
ATP-binding cassette sub-family C member 8 (Q09427)
ATP-binding cassette sub-family C member 8 (UniProt Q09427): 31 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 158 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q09427
- Protein
- ATP-binding cassette sub-family C member 8
- Experimental structures
- 31
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 158 · 11 records with a druggable one
Structures
32 records of Q09427 in the MolNFT archive: 31 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5TWV | Cryo-EM structure of the pancreatic ATP-sensitive K+ channel SUR1/Kir6.2 in the presence of ATP and… | electron microscopy | B, D, F, H | — | 14 (best 0.83) |
| 5TWV | Cryo-EM structure of the pancreatic ATP-sensitive K+ channel SUR1/KIR6.2 in the presence of ATP and… | electron microscopy | B, D, F, H | — | — |
| 6BAA | Cryo-EM structure of the pancreatic beta-cell KATP channel bound to ATP and glibenclamide | electron microscopy | E, F, G, H | GBM | — |
| 6BAA | Cryo-EM structure of the pancreatic beta-cell katp channel bound to ATP and glibenclamide | electron microscopy | E, F, G, H | GBM | — |
| 6PZ9 | Cryo-EM structure of the pancreatic beta-cell SUR1 bound to ATP and repaglinide | electron microscopy | C | BJX, ATP | — |
| 6PZ9 | Cryo-EM structure of the pancreatic beta-cell SUR1 bound to ATP and repaglinide | electron microscopy | C | BJX, ATP | — |
| 6PZA | Cryo-EM structure of the pancreatic beta-cell SUR1 bound to ATP and glibenclamide | electron microscopy | C | GBM, ATP | 20 (best 0.88) |
| 6PZA | Cryo-EM structure of the pancreatic beta-cell SUR1 bound to ATP and glibenclamide | electron microscopy | C | GBM, ATP | — |
| 6PZB | Cryo-EM structure of the pancreatic beta-cell SUR1 Apo state | electron microscopy | G | — | 20 (best 0.85) |
| 6PZB | Cryo-EM structure of the pancreatic beta-cell SUR1 apo state | electron microscopy | G | — | — |
| 6PZC | Cryo-EM structure of the pancreatic beta-cell SUR1 bound to carbamazepine | electron microscopy | H | — | 20 (best 0.83) |
| 6PZC | Cryo-EM structure of the pancreatic beta-cell SUR1 bound to carbamazepine | electron microscopy | H | — | — |
| 6PZI | Cryo-EM structure of the pancreatic beta-cell SUR1 bound to ATP only | electron microscopy | G | ATP | 20 (best 0.84) |
| 6PZI | Cryo-EM structure of the pancreatic beta-cell SUR1 bound to ATP only | electron microscopy | G | ATP | — |
| 7TYS | Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to ATP and repaglinide… | electron microscopy | E | NAG, POV, 65I, BJX, ATP | — |
| 7TYT | Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to ATP and repaglinide… | electron microscopy | E | NAG, POV, PTY, BJX, ATP | — |
| 7U1E | Cryoem structure of the pancreatic ATP-sensitive potassium channel bound to ATP with KIR6.2-ctd in… | electron microscopy | E | ATP, NAG | — |
| 7U1Q | Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to ATP and repaglinide… | electron microscopy | E | NAG, POV, PTY, P5S, BJX, ATP | 12 (best 0.89) |
| 7U1Q | Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to ATP and repaglinide… | electron microscopy | E | NAG, POV, PTY, BJX, ATP | — |
| 7U1S | Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to ATP and repaglinide… | electron microscopy | E | NAG, POV, P5S, PTY, BJX, ATP | 11 (best 0.89) |
| 7U1S | Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to ATP and repaglinide… | electron microscopy | E | NAG, POV, PTY, BJX, ATP | — |
| 7U24 | Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to ATP and glibenclamide… | electron microscopy | E | PTY, POV, ATP, GBM, NAG | — |
| 7U2X | Cryo-EM structure of the pancreatic ATP-sensitive potassium channel in the presence of… | electron microscopy | E | POV, PTY, P5S, ATP, NAG | 11 (best 0.85) |
| 7U2X | Cryo-EM structure of the pancreatic ATP-sensitive potassium channel in the presence of… | electron microscopy | E | POV, PTY, ATP, NAG | — |
| 7U6Y | Cryo-EM structure of the pancreatic ATP-sensitive potassium channel in the presence of… | electron microscopy | E | ATP | 10 (best 0.81) |
| 7U6Y | Cryo-EM structure of the pancreatic ATP-sensitive potassium channel in the presence of… | electron microscopy | E | — | — |
| 7U7M | Cryo-EM structure of the pancreatic ATP-sensitive potassium channel in the presence of… | electron microscopy | E | ATP | 9 (best 0.81) |
| 7U7M | Cryo-EM structure of the pancreatic ATP-sensitive potassium channel in the presence of… | electron microscopy | E | ATP | — |
| 7UAA | Cryoem structure of the pancreatic ATP-sensitive potassium channel in the ATP-bound state with… | electron microscopy | E | ATP | — |
| 7UQR | Cryo-EM structure of the pancreatic ATP-sensitive potassium channel in the apo form with Kir6.2-CTD… | electron microscopy | E | — | 11 (best 0.79) |
| 7UQR | Cryo-EM structure of the pancreatic ATP-sensitive potassium channel in the apo form with KIR6.2-ctd… | electron microscopy | E | — | — |
| Q09427 | AlphaFold monomer V2.0 prediction for ATP-binding cassette sub-family C member 8 (Q09427) | predicted | A | — | — |
Ligands
- ATP · Adenosine-5'-triphosphate · in 20 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 10 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 9 records
- BJX · Repaglinide · in 8 records
- PTY · Phosphatidylethanolamine · in 8 records
- GBM · 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl) sulfamoyl]phenyl}ethyl)-2-methoxybenzamide · in 5 records
- P5S · O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy) propyl]oxy}(hydroxy)phosphoryl]-L-serine · in 3 records
- 65I · (9R,12R)-15-amino-12-hydroxy-6,12-dioxo-7,11,13-trioxa-12lambda~5~-phosphapentadecan-9-yl undecanoate · in 1 record
Experiment against prediction
- 6PZA chain C against the predicted model Q09427: TM-score 0.98, RMSD 1.72 Å
- 6PZA chain C against the predicted model Q09427: TM-score 0.98, RMSD 1.72 Å
- 7U24 chain E against the predicted model Q09427: TM-score 0.98, RMSD 1.73 Å
- 7UQR chain E against the predicted model Q09427: TM-score 0.98, RMSD 1.80 Å
- 7UQR chain E against the predicted model Q09427: TM-score 0.98, RMSD 1.80 Å
- 6PZI chain G against the predicted model Q09427: TM-score 0.98, RMSD 1.76 Å
- 6PZI chain G against the predicted model Q09427: TM-score 0.98, RMSD 1.76 Å
- 7U2X chain E against the predicted model Q09427: TM-score 0.98, RMSD 1.92 Å
- 7U1E chain E against the predicted model Q09427: TM-score 0.98, RMSD 1.84 Å
- 7U6Y chain E against the predicted model Q09427: TM-score 0.98, RMSD 1.92 Å
Elsewhere
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