MolNFT v1 · #188695 · protein
Cryo-EM structure of the pancreatic ATP-sensitive potassium channel in the presence of glibenclamide and ATP with KIR6.2-ctd in the down conformation
7U6Y · ATP-sensitive inward rectifier potassium channel 11: “Cryo-EM structure of the pancreatic ATP-sensitive potassium channel in the presence of glibenclamide and ATP…”. Electron microscopy, 20 pockets (best druggability 0.83). MolNFT…
- PDB
- 7U6Y
- Type
- protein
- Length
- 2,711 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-sensitive inward rectifier potassium channel 11; ATP-binding cassette sub-family C…
- UniProt
- P70673, Q09427
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · 4 distinct chains · 50% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ATP-sensitive inward rectifier potassium channel 11 | protein | 322 | 32% helix, 23% strand | P70673 |
| B, D | ATP-sensitive inward rectifier potassium channel 11 | protein | 321 | 30% helix, 25% strand | P70673 |
| C | ATP-sensitive inward rectifier potassium channel 11 | protein | 323 | 31% helix, 27% strand | P70673 |
| E | ATP-binding cassette sub-family C member 8 | protein | 1424 | 63% helix, 5% strand | Q09427 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 984 | 0.83 | 0.84 | 138 | empty |
| 2 | 839 | 0.81 | 0.84 | 104 | empty |
| 3 | 875 | 0.81 | 0.84 | 100 | empty |
| 4 | 581 | 0.81 | 0.87 | 94 | empty |
| 5 | 534 | 0.80 | 0.87 | 89 | empty |
Interfaces
7 interfaces between chains.
- C–D · 975 Ų buried · 8 hydrogen bonds · protein-protein
- A–B · 959 Ų buried · 12 hydrogen bonds · protein-protein
- A–D · 952 Ų buried · 9 hydrogen bonds · protein-protein
- B–C · 932 Ų buried · 7 hydrogen bonds · protein-protein
- A–E · 451 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7U6Y · Cryo-EM structure of the pancreatic ATP-sensitive potassium channel in the presence of… · the same entry in another collection · chain A against A, TM-score 1.00
- Q09427 · AlphaFold monomer V2.0 prediction for ATP-binding cassette sub-family C member 8 (Q09427) · a predicted model of the same protein · chain E against A, TM-score 0.98
- P70673 · AlphaFold monomer V2.0 prediction for ATP-sensitive inward rectifier potassium channel 11… · a predicted model of the same protein · chain B against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P70673
- Every structure of UniProt Q09427
- Elsewhere: RCSB PDB 7U6Y · PDBe 7U6Y · UniProt P70673 · UniProt Q09427
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