MolNFT v1 · #160954 · protein

Cryo-EM structure of the pancreatic beta-cell SUR1 bound to ATP and glibenclamide

6PZA: “Cryo-EM structure of the pancreatic beta-cell SUR1 bound to ATP and glibenclamide”. Electron microscopy, 2 ligands (GBM, ATP). MolNFT v1 #160954 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6PZA
Type: protein
Length: 1,441 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q09427, P70673
Ligands: GBM, ATP

Structure

electron microscopy · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
C	—	protein	1422	—	Q09427
D	—	protein	19	—	P70673

Ligands and binding sites

GBM · 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl) sulfamoyl]phenyl}ethyl)-2-methoxybenzamide · ligand · chains C, D
ATP · Adenosine-5'-triphosphate · ligand · chains C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6PZA · Cryo-EM structure of the pancreatic beta-cell SUR1 bound to ATP and glibenclamide · the same entry in another collection · chain C against C, TM-score 1.00
Q09427 · AlphaFold monomer V2.0 prediction for ATP-binding cassette sub-family C member 8 (Q09427) · a predicted model of the same protein · chain C against A, TM-score 0.98
P70673 · AlphaFold monomer V2.0 prediction for ATP-sensitive inward rectifier potassium channel 11… · a predicted model of the same protein · chain D against A, TM-score 0.17

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q09427
Every structure of UniProt P70673
Elsewhere: RCSB PDB 6PZA · PDBe 6PZA · UniProt Q09427 · UniProt P70673

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