MolNFT v1 · #188951 · protein
Cryo-EM structure of the pancreatic ATP-sensitive potassium channel in the apo form with KIR6.2-ctd in the down conformation
7UQR · ATP-sensitive inward rectifier potassium channel 11: “Cryo-EM structure of the pancreatic ATP-sensitive potassium channel in the apo form with KIR6.2-ctd in the…”. Electron microscopy, 20 pockets (best druggability 0.83). MolNFT v1…
- PDB
- 7UQR
- Type
- protein
- Length
- 2,730 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-sensitive inward rectifier potassium channel 11; ATP-binding cassette sub-family C…
- UniProt
- P70673, Q09427
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · 3 distinct chains · 53% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ATP-sensitive inward rectifier potassium channel 11 | protein | 327 | 31% helix, 24% strand | P70673 |
| B, C, D | ATP-sensitive inward rectifier potassium channel 11 | protein | 326 | 32% helix, 21% strand | P70673 |
| E | ATP-binding cassette sub-family C member 8 | protein | 1425 | 63% helix, 5% strand | Q09427 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1187 | 0.83 | 0.85 | 167 | empty |
| 2 | 808 | 0.83 | 0.86 | 132 | empty |
| 3 | 702 | 0.83 | 0.87 | 112 | empty |
| 4 | 708 | 0.81 | 0.86 | 122 | empty |
| 5 | 809 | 0.80 | 0.84 | 98 | empty |
Interfaces
7 interfaces between chains.
- A–B · 1002 Ų buried · 12 hydrogen bonds · protein-protein
- A–D · 995 Ų buried · 8 hydrogen bonds · protein-protein
- C–D · 966 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 934 Ų buried · 10 hydrogen bonds · protein-protein
- A–E · 303 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7UQR · Cryo-EM structure of the pancreatic ATP-sensitive potassium channel in the apo form with… · the same entry in another collection · chain E against E, TM-score 1.00
- Q09427 · AlphaFold monomer V2.0 prediction for ATP-binding cassette sub-family C member 8 (Q09427) · a predicted model of the same protein · chain E against A, TM-score 0.98
- P70673 · AlphaFold monomer V2.0 prediction for ATP-sensitive inward rectifier potassium channel 11… · a predicted model of the same protein · chain B against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P70673
- Every structure of UniProt Q09427
- Elsewhere: RCSB PDB 7UQR · PDBe 7UQR · UniProt P70673 · UniProt Q09427
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