MolNFT v1 · #188716 · protein

Cryo-EM structure of the pancreatic ATP-sensitive potassium channel in the presence of carbamazepine and ATP with KIR6.2-ctd in the up conformation

7U7M: “Cryo-EM structure of the pancreatic ATP-sensitive potassium channel in the presence of carbamazepine and ATP…”. Electron microscopy, 1 ligand (ATP). MolNFT v1 #188716 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7U7M
Type: protein
Length: 2,737 residues
Chains: 5
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P70673, Q09427
Ligands: ATP

Structure

electron microscopy · 4 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	326	—	P70673
B, D	—	protein	327	—	P70673
C	—	protein	328	—	P70673
E	—	protein	1429	—	Q09427

Ligands and binding sites

ATP · Adenosine-5'-triphosphate · ligand · chains E

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7U7M · Cryo-EM structure of the pancreatic ATP-sensitive potassium channel in the presence of… · the same entry in another collection · chain E against E, TM-score 1.00
P70673 · AlphaFold monomer V2.0 prediction for ATP-sensitive inward rectifier potassium channel 11… · a predicted model of the same protein · chain C against A, TM-score 0.99
Q09427 · AlphaFold monomer V2.0 prediction for ATP-binding cassette sub-family C member 8 (Q09427) · a predicted model of the same protein · chain E against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P70673
Every structure of UniProt Q09427
Elsewhere: RCSB PDB 7U7M · PDBe 7U7M · UniProt P70673 · UniProt Q09427

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