Research workbench
Cryo-EM structure of the pancreatic ATP-sensitive potassium channel in the presence of carbamazepine and ATP with KIR6.2-ctd in the up conformation
Analyse Cryo-EM structure of the pancreatic ATP-sensitive potassium channel in the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7U7M
- Type
- protein
- Length
- 2,737 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-sensitive inward rectifier potassium channel 11; ATP-binding cassette sub-family C…
- UniProt
- P70673, Q09427
- Ligands
- ATP
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · 4 distinct chains · 50% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ATP-sensitive inward rectifier potassium channel 11 | protein | 326 | 32% helix, 28% strand | P70673 |
| B, D | ATP-sensitive inward rectifier potassium channel 11 | protein | 327 | 32% helix, 28% strand | P70673 |
| C | ATP-sensitive inward rectifier potassium channel 11 | protein | 328 | 32% helix, 26% strand | P70673 |
| E | ATP-binding cassette sub-family C member 8 | protein | 1429 | 62% helix, 6% strand | Q09427 |
Ligands and binding sites
- ATP · Adenosine-5'-triphosphate · ligand · chains E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 696 | 0.83 | 0.88 | 105 | empty |
| 2 | 740 | 0.83 | 0.87 | 102 | empty |
| 3 | 654 | 0.82 | 0.87 | 98 | empty |
| 4 | 595 | 0.82 | 0.87 | 107 | empty |
| 5 | 553 | 0.81 | 0.87 | 93 | empty |
Interfaces
8 interfaces between chains.
- C–D · 1186 Ų buried · 5 hydrogen bonds · protein-protein
- A–B · 1137 Ų buried · 5 hydrogen bonds · protein-protein
- A–D · 1068 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 1061 Ų buried · 2 hydrogen bonds · protein-protein
- A–E · 615 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7U7M · Cryo-EM structure of the pancreatic ATP-sensitive potassium channel in the presence of… · the same entry in another collection · chain E against E, TM-score 1.00
- P70673 · AlphaFold monomer V2.0 prediction for ATP-sensitive inward rectifier potassium channel 11… · a predicted model of the same protein · chain C against A, TM-score 0.99
- Q09427 · AlphaFold monomer V2.0 prediction for ATP-binding cassette sub-family C member 8 (Q09427) · a predicted model of the same protein · chain E against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P70673
- Every structure of UniProt Q09427
- Elsewhere: RCSB PDB 7U7M · PDBe 7U7M · UniProt P70673 · UniProt Q09427
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