MolNFT v1 · #188635 · protein
Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to ATP and repaglinide with SUR1-out conformation
7U1S: “Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to ATP and repaglinide with…”. Electron microscopy, 6 ligands (PTY, ATP, POV). MolNFT v1 #188635 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7U1S
- Type
- protein
- Length
- 2,798 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P70673, Q09427
- Ligands
- PTY, ATP, POV, BJX, NAG, K
Structure
electron microscopy · 5 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 362 | — | P70673 |
| B | — | protein | 332 | — | P70673 |
| C | — | protein | 333 | — | P70673 |
| D | — | protein | 331 | — | P70673 |
| E | — | protein | 1440 | — | Q09427 |
Ligands and binding sites
- PTY · Phosphatidylethanolamine · ligand · 6 copies · chains A, E
- ATP · Adenosine-5'-triphosphate · ligand · 5 copies · chains A, D, B, C, E
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · ligand · 5 copies · chains A, D, E, B, C
- BJX · Repaglinide · ligand · chains A, E
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains E
- K · Potassium ion · metal · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7U1S · Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to ATP and… · the same entry in another collection · chain E against E, TM-score 1.00
- P70673 · AlphaFold monomer V2.0 prediction for ATP-sensitive inward rectifier potassium channel 11… · a predicted model of the same protein · chain D against A, TM-score 0.98
- Q09427 · AlphaFold monomer V2.0 prediction for ATP-binding cassette sub-family C member 8 (Q09427) · a predicted model of the same protein · chain E against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P70673
- Every structure of UniProt Q09427
- Elsewhere: RCSB PDB 7U1S · PDBe 7U1S · UniProt P70673 · UniProt Q09427
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