MolNFT v1 · #135363 · protein
Cryo-EM structure of the pancreatic ATP-sensitive K+ channel SUR1/KIR6.2 in the presence of ATP and glibenclamide
5TWV · ATP-sensitive inward rectifier potassium channel 11: “Cryo-EM structure of the pancreatic ATP-sensitive K+ channel SUR1/KIR6.2 in the presence of ATP and…”. Electron microscopy, 1 ligand (ATP), 20 pockets (best druggability 0.85).…
- PDB
- 5TWV
- Type
- protein
- Length
- 6,800 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-sensitive inward rectifier potassium channel 11; ATP-binding cassette sub-family C…
- UniProt
- Q09427
- Ligands
- ATP
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 2 distinct chains · 57% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E, G | ATP-sensitive inward rectifier potassium channel 11 | protein | 325 | 31% helix, 25% strand | — |
| B, D, F, H | ATP-binding cassette sub-family C member 8 | protein | 1375 | 64% helix, 7% strand | Q09427 |
Ligands and binding sites
- ATP · Adenosine-5'-triphosphate · ligand · 4 copies · chains A, C, E, G
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 432 | 0.85 | 0.92 | 82 | empty |
| 2 | 451 | 0.85 | 0.92 | 59 | empty |
| 3 | 729 | 0.83 | 0.87 | 68 | empty |
| 4 | 1107 | 0.83 | 0.84 | 155 | empty |
| 5 | 616 | 0.83 | 0.87 | 94 | empty |
Interfaces
14 interfaces between chains.
- A–G · 3099 Ų buried · 18 hydrogen bonds · protein-protein
- A–C · 3096 Ų buried · 19 hydrogen bonds · protein-protein
- C–E · 3088 Ų buried · 19 hydrogen bonds · protein-protein
- E–G · 3088 Ų buried · 19 hydrogen bonds · protein-protein
- C–D · 1186 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 5TWV · Cryo-EM structure of the pancreatic ATP-sensitive K+ channel SUR1/Kir6.2 in the presence… · the same entry in another collection · chain H against H, TM-score 1.00
- Q09427 · AlphaFold monomer V2.0 prediction for ATP-binding cassette sub-family C member 8 (Q09427) · a predicted model of the same protein · chain H against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q09427
- Elsewhere: RCSB PDB 5TWV · PDBe 5TWV · UniProt Q09427
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