UniProt Q03720
Isoform J of Calcium-activated potassium channel slowpoke (Q03720)
Isoform J of Calcium-activated potassium channel slowpoke (UniProt Q03720): 6 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 56 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q03720
- Protein
- Isoform J of Calcium-activated potassium channel slowpoke
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 56 · 3 records with a druggable one
Structures
7 records of Q03720 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7PXE | Ca2+ bound Drosophila Slo channel | electron microscopy | A, B, C, D | CA, MG, 6PL, CLR, K | 20 (best 0.79) |
| 7PXE | CA2+ bound drosophila slo channel | electron microscopy | A, B, C, D | CA, MG, 6PL, CLR, K | — |
| 7PXF | CA2+ free drosophila slo channel | electron microscopy | A, B, C, D | MG, K | — |
| 7PXG | Verruculogen-bound drosophila slo channel | electron microscopy | A, B, C, D | 8H5, CA, MG, 6PL, CLR, K | — |
| 7PXH | Emodepside-bound Drosophila Slo channel | electron microscopy | A, B, C, D | CA, MG, 6PL, CLR, K, 8I2 | 20 (best 0.80) |
| 7PXH | Emodepside-bound drosophila slo channel | electron microscopy | A, B, C, D | CA, MG, 6PL, CLR, K, 8I2 | — |
| Q03720 | AlphaFold monomer V2.0 prediction for calcium-activated potassium channel slowpoke (Q03720) | predicted | A | — | 16 (best 0.80) |
Ligands
- K · Potassium ion · in 6 records
- MG · Magnesium ion · in 6 records
- 6PL · (4S,7R)-4-hydroxy-N,N,N-trimethyl-9-oxo-7-[(palmitoyloxy)methyl]-3,5,8-trioxa-4-phosphahexacosan-1-aminium 4-oxide · in 5 records
- CA · Calcium ion · in 5 records
- CLR · Cholesterol · in 5 records
- 8I2 · (3~{S},6~{R},9~{S},12~{R},15~{S},18~{R},21~{S},24~{R})-4,6,10,16,18,22-hexamethyl-3,9,15,21-tetrakis(2-methylpropyl)-12,24-bis[(4-morpholin-4-ylphenyl) methyl]-1,7,13,19-tetraoxa-4,10,16,22-tetrazacyclotetracosane-2,5,8,11,14,17,20,23-octone · in 2 records
- 8H5 · Verruculogen · in 1 record
Experiment against prediction
- 7PXG chain A against the predicted model Q03720: TM-score 0.97, RMSD 1.90 Å
- 7PXH chain C against the predicted model Q03720: TM-score 0.96, RMSD 1.99 Å
- 7PXH chain D against the predicted model Q03720: TM-score 0.96, RMSD 1.99 Å
- 7PXH chain A against the predicted model Q03720: TM-score 0.96, RMSD 2.00 Å
- 7PXH chain B against the predicted model Q03720: TM-score 0.96, RMSD 2.00 Å
- 7PXH chain A against the predicted model Q03720: TM-score 0.96, RMSD 2.00 Å
- 7PXE chain D against the predicted model Q03720: TM-score 0.96, RMSD 2.01 Å
- 7PXE chain A against the predicted model Q03720: TM-score 0.96, RMSD 2.01 Å
- 7PXE chain B against the predicted model Q03720: TM-score 0.96, RMSD 2.01 Å
- 7PXE chain A against the predicted model Q03720: TM-score 0.96, RMSD 2.01 Å
Elsewhere
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