MolNFT v1 · #185467 · protein

CA2+ free drosophila slo channel

7PXF · Isoform J of calcium-activated potassium channel slowpoke: “CA2+ free drosophila slo channel”. Electron microscopy, 2 ligands (MG, K), 20 pockets (best druggability 0.78). MolNFT v1 #185467 on GenesisL1: 3D structure, binding sites…

PDB: 7PXF
Type: protein
Length: 3,540 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Isoform J of calcium-activated potassium channel slowpoke
UniProt: Q03720
Ligands: MG, K
Pockets: 20 · best druggability 0.78

Structure

electron microscopy · 1 distinct chain · 46% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Isoform J of calcium-activated potassium channel slowpoke	protein	885	46% helix, 15% strand	Q03720

Ligands and binding sites

MG · Magnesium ion · metal · 4 copies · chains A, B, C, D
K · Potassium ion · metal · 3 copies · chains A, B, C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	155	0.78	0.95	28	empty
2	159	0.78	0.94	27	empty
3	159	0.77	0.94	29	empty
4	155	0.77	0.94	27	empty
5	1189	0.77	0.78	92	empty

Interfaces

6 interfaces between chains.

A–D · 1856 Å² buried · 11 hydrogen bonds · protein-protein
B–D · 1818 Å² buried · 9 hydrogen bonds · protein-protein
A–C · 1816 Å² buried · 10 hydrogen bonds · protein-protein
B–C · 1808 Å² buried · 10 hydrogen bonds · protein-protein
A–B · 35 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

7PXF · Ca2+ free Drosophila Slo channel · the same entry in another collection · chain A against A, TM-score 1.00
Q03720 · AlphaFold monomer V2.0 prediction for calcium-activated potassium channel slowpoke… · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q03720
Elsewhere: RCSB PDB 7PXF · PDBe 7PXF · UniProt Q03720

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.