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Ligand · 8I2

8I2 · (3~{S},6~{R},9~{S},12~{R},15~{S},18~{R},21~{S},24~{R})-4,6,10,16,18,22-hexamethyl-3,9,15,21-tetrakis(2-methylpropyl)-12,24-bis[(4-morpholin-4-ylphenyl) methyl]-1,7,13,19-tetraoxa-4,10,16,22-tetrazacyclotetracosane-2,5,8,11,14,17,20,23-octone

8I2, (3~{S},6~{R},9~{S},12~{R},15~{S},18~{R},21~{S},24~{R})-4,6,10,16,18,22-hexamethyl-3,9,15,21-tetrakis(2-methylpropyl)-12,24-bis[(4-morpholin-4-ylphenyl)…

Component
8I2
Formula
C60 H90 N6 O14
Class
ligand
Structures
2
PDB entries
1

Binding sites

8I2 in 2 structures; the first of them:

  • 7PXH · Emodepside-bound Drosophila Slo channel · 8I2 B1209 · binds PHE257, ILE296, MET299, SER300, THR301, LEU326, ALA327, PHE329 and 28 more
  • 7PXH · Emodepside-bound drosophila slo channel · 8I2 B1209 · binds PHE257, ILE296, MET299, THR301, LEU326, ALA327, PHE329, ALA330 and 24 more

Residues it binds most

LEU 2, PHE 2, ALA 2, ILE 2, THR 2, SER 2, MET 2, PRO 2 (residue and the binding sites it lines).

Found with

  • 6PL · (4S,7R)-4-hydroxy-N,N,N-trimethyl-9-oxo-7-[(palmitoyloxy)methyl]-3,5,8-trioxa-4-phosphahexacosan-1-aminium 4-oxide
  • CLR · Cholesterol
  • CA · Calcium ion
  • K · Potassium ion
  • MG · Magnesium ion

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