MolNFT v1 · #185466 · protein

CA2+ bound drosophila slo channel

7PXE · Isoform J of calcium-activated potassium channel slowpoke: “CA2+ bound drosophila slo channel”. Electron microscopy, 5 ligands (6PL, CLR, CA), 20 pockets (best druggability 0.79). MolNFT v1 #185466 on GenesisL1: 3D structure…

PDB: 7PXE
Type: protein
Length: 3,540 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Isoform J of calcium-activated potassium channel slowpoke
UniProt: Q03720
Ligands: 6PL, CLR, CA, MG, K
Pockets: 20 · best druggability 0.79

Structure

electron microscopy · 1 distinct chain · 48% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Isoform J of calcium-activated potassium channel slowpoke	protein	885	48% helix, 15% strand	Q03720

Ligands and binding sites

6PL · (4S,7R)-4-hydroxy-N,N,N-trimethyl-9-oxo-7-[(palmitoyloxy)methyl]-3,5,8-trioxa-4-phosphahexacosan-1-aminium 4-oxide · ligand · 16 copies · chains A, C, D, B
CLR · Cholesterol · ligand · 4 copies · chains A, B, C, D
CA · Calcium ion · metal · 8 copies · chains A, C, B, D
MG · Magnesium ion · metal · 4 copies · chains A, B, C, D
K · Potassium ion · metal · 4 copies · chains A, B, C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	799	0.79	0.82	85	empty
2	839	0.78	0.81	86	empty
3	998	0.77	0.79	73	empty
4	951	0.77	0.80	67	empty
5	996	0.77	0.79	68	empty

Interfaces

6 interfaces between chains.

B–D · 2319 Å² buried · 20 hydrogen bonds · protein-protein
A–C · 2291 Å² buried · 15 hydrogen bonds · protein-protein
A–D · 2275 Å² buried · 17 hydrogen bonds · protein-protein
B–C · 2268 Å² buried · 17 hydrogen bonds · protein-protein
C–D · 34 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

7PXE · Ca2+ bound Drosophila Slo channel · the same entry in another collection · chain A against A, TM-score 1.00
Q03720 · AlphaFold monomer V2.0 prediction for calcium-activated potassium channel slowpoke… · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q03720
Elsewhere: RCSB PDB 7PXE · PDBe 7PXE · UniProt Q03720

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.