MolNFT v1 · #185468 · protein

Verruculogen-bound drosophila slo channel

7PXG · Isoform J of calcium-activated potassium channel slowpoke: “Verruculogen-bound drosophila slo channel”. Electron microscopy, 6 ligands (6PL, 8H5, CLR), 20 pockets (best druggability 0.79). MolNFT v1 #185468 on GenesisL1: 3D…

PDB: 7PXG
Type: protein
Length: 3,540 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Isoform J of calcium-activated potassium channel slowpoke
UniProt: Q03720
Ligands: 6PL, 8H5, CLR, CA, MG, K
Pockets: 20 · best druggability 0.79

Structure

electron microscopy · 1 distinct chain · 48% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Isoform J of calcium-activated potassium channel slowpoke	protein	885	48% helix, 15% strand	Q03720

Ligands and binding sites

6PL · (4S,7R)-4-hydroxy-N,N,N-trimethyl-9-oxo-7-[(palmitoyloxy)methyl]-3,5,8-trioxa-4-phosphahexacosan-1-aminium 4-oxide · ligand · 8 copies · chains A, B, D, C
8H5 · Verruculogen · ligand · 4 copies · chains A, C, D, B
CLR · Cholesterol · ligand · 4 copies · chains A, B, C, D
CA · Calcium ion · metal · 8 copies · chains A, C, B, D
MG · Magnesium ion · metal · 4 copies · chains A, B, C, D
K · Potassium ion · metal · 4 copies · chains A, B, C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	844	0.79	0.82	86	empty
2	794	0.79	0.82	83	empty
3	783	0.79	0.82	76	empty
4	266	0.77	0.90	32	empty
5	987	0.74	0.77	72	empty

Interfaces

6 interfaces between chains.

B–D · 2184 Å² buried · 16 hydrogen bonds · protein-protein
A–C · 2183 Å² buried · 15 hydrogen bonds · protein-protein
B–C · 2104 Å² buried · 12 hydrogen bonds · protein-protein
A–D · 2090 Å² buried · 13 hydrogen bonds · protein-protein
C–D · 32 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

7PXG · Verruculogen-bound Drosophila Slo channel · the same entry in another collection · chain A against A, TM-score 1.00
Q03720 · AlphaFold monomer V2.0 prediction for calcium-activated potassium channel slowpoke… · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q03720
Elsewhere: RCSB PDB 7PXG · PDBe 7PXG · UniProt Q03720

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