UniProt P78527
DNA-dependent protein kinase catalytic subunit (P78527)
DNA-dependent protein kinase catalytic subunit (UniProt P78527), EC 2.7.11.1: 67 experimental structures on GenesisL1, 8 ligands bound, 649 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P78527
- Protein
- DNA-dependent protein kinase catalytic subunit
- EC
- 2.7.11.1
- Experimental structures
- 67
- Predicted models
- 0
- Ligands
- 8
- Pockets
- 649 · 36 records with a druggable one
Structures
67 records of P78527 in the MolNFT archive: 67 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5LUQ | Crystal Structure of Human DNA-dependent Protein Kinase Catalytic Subunit (DNA-PKcs) | x-ray diffraction | A, B | — | 20 (best 0.87) |
| 5LUQ | Crystal structure of human DNA-dependent protein kinase catalytic subunit (DNA-pkcs) | x-ray diffraction | A, B | — | — |
| 5W1R | Cryo-EM structure of DNAPKcs | electron microscopy | A | — | 20 (best 0.89) |
| 5W1R | Cryo-EM structure of dnapkcs | electron microscopy | A | — | — |
| 5Y3R | Cryo-EM structure of Human DNA-PK Holoenzyme | electron microscopy | C | — | — |
| 5Y3R | Cryo-EM structure of human DNA-pk holoenzyme | electron microscopy | C | — | — |
| 6ZFP | Cryo-EM structure of DNA-PKcs (State 2) | electron microscopy | A | — | 20 (best 0.84) |
| 6ZFP | Cryo-EM structure of DNA-pkcs (state 2) | electron microscopy | A | — | — |
| 6ZH2 | Cryo-EM structure of DNA-PKcs (State 1) | electron microscopy | A | — | 20 (best 0.86) |
| 6ZH2 | Cryo-EM structure of DNA-pkcs (state 1) | electron microscopy | A | — | — |
| 6ZH4 | Cryo-EM structure of DNA-PKcs (State 3) | electron microscopy | A | — | 20 (best 0.87) |
| 6ZH4 | Cryo-EM structure of DNA-pkcs (state 3) | electron microscopy | A | — | — |
| 6ZH6 | Cryo-EM structure of DNA-PKcs:Ku80ct194 | electron microscopy | A | — | 20 (best 0.87) |
| 6ZH6 | Cryo-EM structure of DNA-PKCS:KU80CT194 | electron microscopy | A | — | — |
| 6ZH8 | Cryo-EM structure of DNA-PKcs:DNA | electron microscopy | A | — | 20 (best 0.87) |
| 6ZH8 | Cryo-EM structure of DNA-PKCS:DNA | electron microscopy | A | — | — |
| 6ZHA | Cryo-EM structure of DNA-PK monomer | electron microscopy | A | — | 14 (best 0.87) |
| 6ZHA | Cryo-EM structure of DNA-pk monomer | electron microscopy | A | — | — |
| 6ZHE | Cryo-EM structure of DNA-PK dimer | electron microscopy | A, F | — | 19 (best 0.91) |
| 6ZHE | Cryo-EM structure of DNA-pk dimer | electron microscopy | A, F | — | — |
| 7K0Y | Cryo-EM structure of activated-form DNA-PK (complex VI) | electron microscopy | A | — | 15 (best 0.83) |
| 7K0Y | Cryo-EM structure of activated-form DNA-pk (complex VI) | electron microscopy | A | — | — |
| 7K10 | CryoEM structure of activated-form FATKIN domain of DNA-PK | electron microscopy | A | — | 20 (best 0.83) |
| 7K10 | Cryoem structure of activated-form fatkin domain of DNA-pk | electron microscopy | A | — | — |
| 7K11 | CryoEM structure of inactivated-form FATKIN domain of DNA-PK | electron microscopy | A | — | 20 (best 0.83) |
| 7K11 | Cryoem structure of inactivated-form fatkin domain of DNA-pk | electron microscopy | A | — | — |
| 7K19 | CryoEM structure of DNA-PK catalytic subunit complexed with DNA (Complex I) | electron microscopy | A | — | 20 (best 0.85) |
| 7K19 | Cryoem structure of DNA-pk catalytic subunit complexed with DNA (complex I) | electron microscopy | A | — | — |
| 7K1B | CryoEM structure of DNA-PK catalytic subunit complexed with DNA (Complex II) | electron microscopy | A | — | 20 (best 0.83) |
| 7K1B | Cryoem structure of DNA-pk catalytic subunit complexed with DNA (complex II) | electron microscopy | A | — | — |
| 7K1J | CryoEM structure of inactivated-form DNA-PK (Complex III) | electron microscopy | A | — | 15 (best 0.85) |
| 7K1J | Cryoem structure of inactivated-form DNA-pk (complex III) | electron microscopy | A | — | — |
| 7K1K | CryoEM structure of inactivated-form DNA-PK (Complex IV) | electron microscopy | A | — | 14 (best 0.86) |
| 7K1K | Cryoem structure of inactivated-form DNA-pk (complex IV) | electron microscopy | A | — | — |
| 7K1N | CryoEM structure of inactivated-form DNA-PK (Complex V) | electron microscopy | A | — | 16 (best 0.84) |
| 7K1N | Cryoem structure of inactivated-form DNA-pk (complex V) | electron microscopy | A | — | — |
| 7LT3 | NHEJ Long-range synaptic complex | electron microscopy | C, L | ADP | 19 (best 0.87) |
| 7LT3 | Nhej long-range synaptic complex | electron microscopy | C, L | ADP | — |
| 7NFC | Cryo-EM structure of NHEJ super-complex (dimer) | electron microscopy | A, F | — | 10 (best 0.84) |
| 7NFC | Cryo-EM structure of nhej super-complex (dimer) | electron microscopy | A, F | — | — |
| 7NFE | Cryo-EM structure of NHEJ super-complex (monomer) | electron microscopy | A | — | 14 (best 0.85) |
| 7NFE | Cryo-EM structure of nhej super-complex (monomer) | electron microscopy | A | — | — |
| 7OTM | Cryo-EM structure of DNA-PKcs in complex with NU7441 | electron microscopy | A | 2R4 | 20 (best 0.85) |
| 7OTM | Cryo-EM structure of DNA-pkcs in complex with NU7441 | electron microscopy | A | 2R4 | — |
| 7OTP | DNA-PKcs in complex with ATPgammaS-Mg | electron microscopy | A | AGS, MG | 20 (best 0.85) |
| 7OTP | DNA-pkcs in complex with atpgammas-mg | electron microscopy | A | AGS, MG | — |
| 7OTV | DNA-PKcs in complex with wortmannin | electron microscopy | A | KWT | 20 (best 0.83) |
| 7OTV | DNA-pkcs in complex with wortmannin | electron microscopy | A | KWT | — |
| 7OTW | DNA-PKcs in complex with AZD7648 | electron microscopy | A | MBW | 20 (best 0.83) |
| 7OTW | DNA-pkcs in complex with AZD7648 | electron microscopy | A | MBW | — |
| 7OTY | DNA-PKcs in complex with M3814 | electron microscopy | A | 1IX | 20 (best 0.83) |
| 7OTY | DNA-pkcs in complex with M3814 | electron microscopy | A | 1IX | — |
| 7SGL | DNA-pk complex of DNA end processing | electron microscopy | A | MG, ATP | — |
| 7SU3 | CryoEM structure of DNA-PK complex VII | electron microscopy | A | ATP | 16 (best 0.81) |
| 7SU3 | Cryoem structure of DNA-pk complex VII | electron microscopy | A | ATP | — |
| 7SUD | CryoEM structure of DNA-PK complex VIII | electron microscopy | A | MG, ATP | 20 (best 0.85) |
| 7SUD | Cryoem structure of DNA-pk complex VIII | electron microscopy | A | MG, ATP | — |
| 7TYR | Cryo-EM structure of the basal state of the Artemis:DNA-PKcs complex (see COMPND 13/14) | electron microscopy | A | — | 20 (best 0.87) |
| 7TYR | Cryo-EM structure of the basal state of the ARTEMIS:DNA-pkcs complex (see compnd 13/14) | electron microscopy | A | — | — |
| 7Z87 | DNA-PK in the active state | electron microscopy | A | 1IX | 17 (best 0.85) |
7 records more on the page itself.
Ligands
- ATP · Adenosine-5'-triphosphate · in 6 records
- MG · Magnesium ion · in 5 records
- 1IX · (~{S})-[2-chloranyl-4-fluoranyl-5-(7-morpholin-4-ylquinazolin-4-yl)phenyl]-(6-methoxypyridazin-3-yl) methanol · in 4 records
- 2R4 · 8-(dibenzo[b,d]thiophen-4-yl)-2-(morpholin-4-yl)-4H-chromen-4-one · in 2 records
- ADP · Adenosine-5'-diphosphate · in 2 records
- AGS · Phosphothiophosphoric acid-adenylate ester · in 2 records
- KWT · (1s,6br,9as,11r,11br)-9A,11B-dimethyl-1-[(methyloxy) methyl]-3,6,9-trioxo-1,6,6B,7,8,9,9A,10,11,11B-decahydro-3H-furo[4, 3,2-de]indeno[4,5-h][2]benzopyran-11-yl acetate · in 2 records
- MBW · 7-methyl-2-[(7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(oxan-4-yl)purin-8-one · in 2 records
Elsewhere
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