MolNFT v1 · #137867 · protein
Cryo-EM structure of dnapkcs
5W1R · DNA-dependent protein kinase catalytic subunit: “Cryo-EM structure of dnapkcs”. Electron microscopy, 20 pockets (best druggability 0.89). MolNFT v1 #137867 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5W1R
- Type
- protein
- Length
- 3,563 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA-dependent protein kinase catalytic subunit
- EC
- 2.7.11.1
- UniProt
- P78527
- Pockets
- 20 · best druggability 0.89
Structure
electron microscopy · 1 distinct chain · 57% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) | protein | 3563 | 57% helix, 1% strand | P78527 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1092 | 0.89 | 0.90 | 130 | empty |
| 2 | 945 | 0.88 | 0.90 | 124 | empty |
| 3 | 865 | 0.88 | 0.91 | 117 | empty |
| 4 | 972 | 0.88 | 0.89 | 138 | empty |
| 5 | 1061 | 0.88 | 0.88 | 127 | empty |
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P78527
- Elsewhere: RCSB PDB 5W1R · PDBe 5W1R · UniProt P78527
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