MolNFT v1 · #179290 · protein
Cryoem structure of inactivated-form fatkin domain of DNA-pk
7K11 · DNA-dependent protein kinase catalytic subunit: “Cryoem structure of inactivated-form fatkin domain of DNA-pk”. Electron microscopy, 20 pockets (best druggability 0.83). MolNFT v1 #179290 on GenesisL1: 3D structure, binding sites…
- PDB
- 7K11
- Type
- protein
- Length
- 1,254 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA-dependent protein kinase catalytic subunit
- EC
- 2.7.11.1
- UniProt
- P78527
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · 1 distinct chain · 54% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) | protein | 1254 | 54% helix, 3% strand | P78527 |
Pockets
20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 726 | 0.83 | 0.87 | 97 | empty |
| 2 | 569 | 0.82 | 0.87 | 79 | empty |
| 3 | 378 | 0.78 | 0.87 | 45 | empty |
| 4 | 113 | 0.77 | 0.97 | 29 | empty |
| 5 | 101 | 0.70 | 0.92 | 30 | empty |
Compared structures
- 7K11 · CryoEM structure of inactivated-form FATKIN domain of DNA-PK · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P78527
- Elsewhere: RCSB PDB 7K11 · PDBe 7K11 · UniProt P78527
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.