MolNFT v1 · #171757 · protein
Cryo-EM structure of DNA-pkcs (state 2)
6ZFP · DNA-dependent protein kinase catalytic SUBUNIT,DNA-pkcs…: “Cryo-EM structure of DNA-pkcs (state 2)”. Electron microscopy, 20 pockets (best druggability 0.84). MolNFT v1 #171757 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 6ZFP
- Type
- protein
- Length
- 3,704 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA-dependent protein kinase catalytic SUBUNIT,DNA-pkcs, DNA-pkcs
- EC
- 2.7.11.1
- UniProt
- P78527
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · 1 distinct chain · 60% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA-dependent protein kinase catalytic SUBUNIT,DNA-pkcs, DNA-pkcs (EC 2.7.11.1) | protein | 3704 | 60% helix, 2% strand | P78527 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 813 | 0.84 | 0.87 | 102 | empty |
| 2 | 1052 | 0.83 | 0.84 | 107 | empty |
| 3 | 1118 | 0.78 | 0.80 | 133 | empty |
| 4 | 801 | 0.78 | 0.82 | 82 | empty |
| 5 | 113 | 0.78 | 0.96 | 22 | empty |
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P78527
- Elsewhere: RCSB PDB 6ZFP · PDBe 6ZFP · UniProt P78527
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