MolNFT v1 · #184547 · protein
DNA-pkcs in complex with atpgammas-mg
7OTP · DNA-dependent protein kinase catalytic SUBUNIT,DNA-pkcs: “DNA-pkcs in complex with atpgammas-mg”. Electron microscopy, 2 ligands (AGS, MG), 20 pockets (best druggability 0.85). MolNFT v1 #184547 on GenesisL1: 3D structure, binding…
- PDB
- 7OTP
- Type
- protein
- Length
- 3,656 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA-dependent protein kinase catalytic SUBUNIT,DNA-pkcs
- EC
- 2.7.11.1
- UniProt
- P78527
- Ligands
- AGS, MG
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 1 distinct chain · 62% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA-dependent protein kinase catalytic SUBUNIT,DNA-pkcs (EC 2.7.11.1) | protein | 3656 | 62% helix, 2% strand | P78527 |
Ligands and binding sites
- AGS · Phosphothiophosphoric acid-adenylate ester · ligand · chains A
- MG · Magnesium ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 878 | 0.85 | 0.87 | 111 | empty |
| 2 | 923 | 0.82 | 0.84 | 89 | empty |
| 3 | 1036 | 0.81 | 0.83 | 109 | empty |
| 4 | 1153 | 0.80 | 0.81 | 126 | empty |
| 5 | 304 | 0.79 | 0.89 | 31 | empty |
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P78527
- Elsewhere: RCSB PDB 7OTP · PDBe 7OTP · UniProt P78527
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