UniProt P61586
Transforming protein RhoA (P61586)
Transforming protein RhoA (UniProt P61586), EC 3.6.5.2: 105 experimental structures and 1 predicted model on GenesisL1, 26 ligands bound, 117 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P61586
- Protein
- Transforming protein RhoA
- EC
- 3.6.5.2
- Experimental structures
- 105
- Predicted models
- 1
- Ligands
- 26
- Pockets
- 117 · 25 records with a druggable one
Structures
106 records of P61586 in the MolNFT archive: 105 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1A2B | Human rhoa complexed with GTP analogue | x-ray diffraction | A | — | — |
| 1A2B | Human rhoa complexed with GTP analogue | x-ray diffraction | A | — | — |
| 1CC0 | Crystal structure of the RHOA.GDP-rhogdi complex | x-ray diffraction | A, C | — | — |
| 1CC0 | Crystal structure of the RHOA.GDP-rhogdi complex | x-ray diffraction | A, C | — | — |
| 1CXZ | Crystal structure of human rhoa complexed with the effector domain of the protein kinase PKN/PRK1 | x-ray diffraction | A | — | — |
| 1CXZ | Crystal structure of human rhoa complexed with the effector domain of the protein kinase PKN/PRK1 | x-ray diffraction | A | — | — |
| 1DPF | Crystal structure of a mg-free form of rhoa complexed with GDP | x-ray diffraction | A | — | — |
| 1DPF | Crystal structure of a mg-free form of rhoa complexed with GDP | x-ray diffraction | A | — | — |
| 1FTN | Crystal structure of the human RHOA/GDP complex | x-ray diffraction | A | — | — |
| 1FTN | Crystal structure of the human RHOA/GDP complex | x-ray diffraction | A | — | — |
| 1KMQ | Crystal Structure of a Constitutively Activated RhoA Mutant (Q63L) | x-ray diffraction | A | — | — |
| 1KMQ | Crystal structure of a constitutively activated rhoa mutant (Q63L) | x-ray diffraction | A | — | — |
| 1LB1 | Crystal Structure of the Dbl and Pleckstrin homology domains of Dbs in complex with RhoA | x-ray diffraction | B, D, F, H | — | — |
| 1LB1 | Crystal structure of the dbl and pleckstrin homology domains of dbs in complex with rhoa | x-ray diffraction | B, D, F, H | — | — |
| 1OW3 | Crystal Structure of RhoA.GDP.MgF3-in Complex with RhoGAP | x-ray diffraction | B | — | — |
| 1OW3 | Crystal structure of RHOA.GDP.MGF3-in complex with rhogap | x-ray diffraction | B | — | — |
| 1S1C | Crystal structure of the complex between the human RhoA and Rho-binding domain of human ROCKI | x-ray diffraction | A, B | — | — |
| 1S1C | Crystal structure of the complex between the human rhoa and rho-binding domain of human rocki | x-ray diffraction | A, B | — | — |
| 1TX4 | RHO/RHOGAP/GDP(DOT)ALF4 complex | x-ray diffraction | B | — | — |
| 1TX4 | RHO/RHOGAP/GDP(DOT)ALF4 complex | x-ray diffraction | B | — | — |
| 1X86 | Crystal Structure of the DH/PH domains of Leukemia-associated RhoGEF in complex with RhoA | x-ray diffraction | B, D, F, H | — | — |
| 1X86 | Crystal structure of the DH/PH domains of leukemia-associated rhogef in complex with rhoa | x-ray diffraction | B, D, F, H | — | — |
| 1XCG | Crystal Structure of Human RhoA in complex with DH/PH fragment of PDZRHOGEF | x-ray diffraction | B, F | — | — |
| 1XCG | Crystal structure of human rhoa in complex with DH/PH fragment of pdzrhogef | x-ray diffraction | B, F | — | — |
| 2RGN | Crystal Structure of p63RhoGEF complex with Galpha-q and RhoA | x-ray diffraction | C, F | — | — |
| 2RGN | Crystal structure of P63RHOGEF complex with galpha-Q and rhoa | x-ray diffraction | C, F | — | — |
| 3KZ1 | Crystal Structure of the Complex of PDZ-RhoGEF DH/PH domains with GTP-gamma-S Activated RhoA | x-ray diffraction | E, F | — | — |
| 3KZ1 | Crystal structure of the complex of PDZ-rhogef DH/PH domains with GTP- gamma-S activated rhoa | x-ray diffraction | E, F | — | — |
| 3LW8 | Shigella IpgB2 in complex with human RhoA, GDP and Mg2+ (complex A) | x-ray diffraction | A, B, C, D | — | — |
| 3LW8 | Shigella IPGB2 in complex with human rhoa, GDP and MG2+ (complex a) | x-ray diffraction | A, B, C, D | — | — |
| 3LWN | Shigella IpgB2 in complex with human RhoA, GDP and Mg2+ (complex B) | x-ray diffraction | A, B | — | — |
| 3LWN | Shigella IPGB2 in complex with human rhoa, GDP and MG2+ (complex B) | x-ray diffraction | A, B | — | — |
| 3LXR | Shigella IpgB2 in complex with human RhoA and GDP (complex C) | x-ray diffraction | A | — | — |
| 3LXR | Shigella IPGB2 in complex with human rhoa and GDP (complex C) | x-ray diffraction | A | — | — |
| 3MSX | Crystal structure of RhoA.GDP.MgF3 in complex with GAP domain of ArhGAP20 | x-ray diffraction | A | — | — |
| 3MSX | Crystal structure of RHOA.GDP.MGF3 in complex with gap domain of ARHGAP20 | x-ray diffraction | A | — | — |
| 3T06 | Crystal Structure of the DH/PH fragment of PDZRHOGEF with N-terminal regulatory elements in complex… | x-ray diffraction | B, F | — | — |
| 3T06 | Crystal structure of the DH/PH fragment of pdzrhogef with N-terminal regulatory elements in complex… | x-ray diffraction | B, F | — | — |
| 4D0N | AKAP13 (AKAP-Lbc) RhoGEF domain in complex with RhoA | x-ray diffraction | A | — | — |
| 4D0N | AKAP13 (akap-lbc) rhogef domain in complex with rhoa | x-ray diffraction | A | — | — |
| 4XH9 | Crystal structure of human rhoa in complex with DH/PH fragment of the guanine nucleotide exchange… | x-ray diffraction | B, E | — | — |
| 4XH9 | Crystal structure of human rhoa in complex with DH/PH fragment of the guanine nucleotide exchange… | x-ray diffraction | B, E | — | — |
| 4XOI | Structure of hsAnillin bound with RhoA(Q63L) at 2.1 Angstroms resolution | x-ray diffraction | A, C | — | — |
| 4XOI | Structure of hsanillin bound with RHOA(Q63L) at 2.1 ångströms resolution | x-ray diffraction | A, C | — | — |
| 4XSG | The complex structure of C3cer exoenzyme and GTP bound RhoA (NADH-free state) | x-ray diffraction | A | — | — |
| 4XSG | The complex structure of C3CER exoenzyme and GTP bound rhoa (NADH-free state) | x-ray diffraction | A | — | — |
| 4XSH | The complex structure of C3cer exoenzyme and GTP bound RhoA (NADH-bound state) | x-ray diffraction | A | GSP, MG, NAI | 4 (best 0.78) |
| 4XSH | The complex structure of C3CER exoenzyme and GTP bound rhoa (NADH- bound state) | x-ray diffraction | A | — | — |
| 5A0F | Crystal structure of Yersinia Afp18-modified RhoA | x-ray diffraction | A | — | — |
| 5A0F | Crystal structure of yersinia AFP18-modified rhoa | x-ray diffraction | A | — | — |
| 5BWM | The complex structure of C3CER exoenzyme and GDP bound rhoa (NADH- bound state) | x-ray diffraction | A | — | — |
| 5C2K | Crystal structure of the fusion protein linked by RhoA and the GAP domain of MgcRacGAP | x-ray diffraction | A | MG, AF3, GDP | 2 (best 0.71) |
| 5C2K | Crystal structure of the fusion protein linked by rhoa and the gap domain of mgcracgap | x-ray diffraction | A | — | — |
| 5C4M | Rhoa GDP with novel switch II conformation | x-ray diffraction | A | — | — |
| 5EZ6 | Crystallization and preliminary X-ray crystallographic analysis of a small GTPase RhoA | x-ray diffraction | B | MG, GDP | — |
| 5EZ6 | Crystallization and preliminary X-ray crystallographic analysis of a small GTPase rhoa | x-ray diffraction | B | — | — |
| 5FR1 | Double acetylated RhoGDI-alpha in complex with RhoA-GDP | x-ray diffraction | A | GDP, MG | — |
| 5FR1 | Double acetylated rhogdi-alpha in complex with rhoa-GDP | x-ray diffraction | A | — | — |
| 5FR2 | Farnesylated rhoa-GDP in complex with rhogdi-alpha, lysine acetylated at K178 | x-ray diffraction | A | — | — |
| 5HPY | Crystal Structure of RhoA.GDP.MgF3-in complex with human Myosin 9b RhoGAP domain | x-ray diffraction | B, F | MGF, MG, GDP | — |
46 records more on the page itself.
Ligands
- MG · Magnesium ion · in 22 records
- GDP · Guanosine-5'-diphosphate · in 19 records
- MGF · Trifluoromagnesate · in 5 records
- GSP · 5'-guanosine-diphosphate-monothiophosphate · in 4 records
- ALF · Tetrafluoroaluminate ion · in 3 records
- 8ZO · Prop-2-enyl (3R)-1,1-bis(oxidanylidene)-2,3-dihydro-1-benzothiophene-3-carboxylate · in 1 record
- AF3 · Aluminum fluoride · in 1 record
- APY · 2-aminomethyl-pyridine · in 1 record
- FAR · Farnesyl · in 1 record
- GNP · Phosphoaminophosphonic acid-guanylate ester · in 1 record
- LFO · N,1-dimethyl-1H-indole-3-carboxamide · in 1 record
- NAI · 1,4-dihydronicotinamide adenine dinucleotide · in 1 record
- PO4 · Phosphate ion · in 1 record
- RA0 · 3-{3-[ethyl(quinolin-2-yl)amino]phenyl}propanoic acid · in 1 record
- UWS · 6-methyl-2-[(3-methyl-1,2-oxazol-5-yl)methyl]pyridazin-3(2H)-one · in 1 record
- WJ7 · 2-bromo-4-fluoro-N,N-dimethylbenzamide · in 1 record
- YX2 · 3-propanamido-1-benzofuran-2-carboxamide · in 1 record
- YX6 · N-[(3R)-6-oxopiperidin-3-yl]-1,3-thiazole-4-carboxamide · in 1 record
- YXB · N-[(1H-indol-4-yl)methyl]ethanamine · in 1 record
- Z3O · (3S)-3-{[(4R)-4-methyl-3,4-dihydropyridin-1(2H)-yl]methyl}-3H-indole · in 1 record
- Z5C · 5-(methoxymethyl)-1,2-oxazole-3-carboxamide · in 1 record
- Z7T · 2-(cyclopentylamino)pyridine-4-carboxamide · in 1 record
- ZC9 · (2P)-5-fluoro-2-(1H-pyrazol-5-yl)pyridine · in 1 record
- ZCI · 2-bromo-1H-imidazole · in 1 record
- ZE9 · 1-[(3R,5R)-5-(furan-2-yl)-3-(5-methylfuran-2-yl)pyrazolidin-1-yl]ethan-1-one · in 1 record
- ZGX · 1-(3,4-dihydropyrazin-1(2H)-yl)ethan-1-one · in 1 record
Experiment against prediction
- 1TX4 chain B against the predicted model P61586: TM-score 0.99, RMSD 0.38 Å
- 1TX4 chain B against the predicted model P61586: TM-score 0.99, RMSD 0.38 Å
- 5IRC chain F against the predicted model P61586: TM-score 0.99, RMSD 0.39 Å
- 5IRC chain F against the predicted model P61586: TM-score 0.99, RMSD 0.39 Å
- 5IRC chain D against the predicted model P61586: TM-score 0.99, RMSD 0.39 Å
- 5IRC chain D against the predicted model P61586: TM-score 0.99, RMSD 0.39 Å
- 1OW3 chain B against the predicted model P61586: TM-score 0.99, RMSD 0.44 Å
- 1OW3 chain B against the predicted model P61586: TM-score 0.99, RMSD 0.44 Å
- 6BCA chain F against the predicted model P61586: TM-score 0.99, RMSD 0.44 Å
- 1KMQ chain A against the predicted model P61586: TM-score 0.99, RMSD 0.45 Å
Elsewhere
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