MolNFT v1 · #13421 · protein

Crystal structure of the dbl and pleckstrin homology domains of dbs in complex with rhoa

1LB1 · Guanine nucleotide exchange factor dbs: “Crystal structure of the dbl and pleckstrin homology domains of dbs in complex with rhoa”. X-ray diffraction, 20 pockets (best druggability 0.61). MolNFT v1 #13421 on GenesisL1: 3D structure…

PDB: 1LB1
Type: protein
Length: 2,008 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Guanine nucleotide exchange factor dbs; Transforming protein rhoa
UniProt: Q64096, P61586
Pockets: 20 · best druggability 0.61

Structure

x-ray diffraction · 2 distinct chains · 51% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C, E, G	Guanine nucleotide exchange factor dbs	protein	324	58% helix, 17% strand	Q64096
B, D, F, H	Transforming protein rhoa	protein	178	38% helix, 22% strand	P61586

Pockets

20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	459	0.61	0.75	36	empty
2	462	0.61	0.75	35	empty
3	474	0.61	0.75	36	empty
4	309	0.59	0.77	36	empty
5	199	0.59	0.81	29	empty

Interfaces

6 interfaces between chains.

E–F · 1712 Å² buried · 21 hydrogen bonds · protein-protein
C–D · 1706 Å² buried · 19 hydrogen bonds · protein-protein
G–H · 1706 Å² buried · 21 hydrogen bonds · protein-protein
A–B · 1692 Å² buried · 19 hydrogen bonds · protein-protein
C–E · 571 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

1LB1 · Crystal Structure of the Dbl and Pleckstrin homology domains of Dbs in complex with RhoA · the same entry in another collection · chain H against H, TM-score 1.00
Q64096 · AlphaFold monomer V2.0 prediction for guanine nucleotide exchange factor dbs (Q64096) · a predicted model of the same protein · chain A against A, TM-score 0.98
P61586 · AlphaFold monomer V2.0 prediction for transforming protein rhoa (P61586) · a predicted model of the same protein · chain B against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q64096
Every structure of UniProt P61586
Elsewhere: RCSB PDB 1LB1 · PDBe 1LB1 · UniProt Q64096 · UniProt P61586

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.