UniProt P60763
Ras-related C3 botulinum toxin substrate 3 (P60763)
Ras-related C3 botulinum toxin substrate 3 (UniProt P60763): 12 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 57 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P60763
- Protein
- Ras-related C3 botulinum toxin substrate 3
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 57 · 11 records with a druggable one
Structures
13 records of P60763 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2C2H | Crystal structure of the human RAC3 in complex with GDP | x-ray diffraction | A, B | GDP, CA, SO4, MG | 1 (best 0.45) |
| 2C2H | Crystal structure of the human RAC3 in complex with GDP | x-ray diffraction | A, B | GDP, CA, SO4, MG | 1 (best 0.45) |
| 2G0N | The Crystal Structure of the Human RAC3 in complex with GDP and Chloride | x-ray diffraction | A, B | MG, CL, GDP | 1 (best 0.79) |
| 2G0N | The crystal structure of the human RAC3 in complex with GDP and chloride | x-ray diffraction | A, B | MG, CL, GDP | 1 (best 0.79) |
| 2IC5 | Crystal structure of human RAC3 grown in the presence of Gpp(NH)p. | x-ray diffraction | A, B | MG, CL, GNP, GDP | 1 (best 0.78) |
| 2IC5 | Crystal structure of human RAC3 grown in the presence of GPP(NH)P. | x-ray diffraction | A, B | MG, CL, GNP, GDP | 1 (best 0.78) |
| 2OV2 | The crystal structure of the human RAC3 in complex with the CRIB domain of human p21-activated… | x-ray diffraction | A, F, B, C, G, D, E, H | MG, CL, GCP | 16 (best 0.87) |
| 2OV2 | The crystal structure of the human RAC3 in complex with the crib domain of human P21-activated… | x-ray diffraction | A, F, B, C, G, D, E, H | MG, CL, GCP | 16 (best 0.87) |
| 2QME | Crystal structure of human RAC3 in complex with CRIB domain of human p21-activated kinase 1 (PAK1) | x-ray diffraction | A | MG, GCP | 1 (best 0.57) |
| 2QME | Crystal structure of human RAC3 in complex with crib domain of human P21-activated kinase 1 (PAK1) | x-ray diffraction | A | GCP, MG | 1 (best 0.57) |
| 6TM1 | Crystal structure of the DHR2 domain of DOCK10 in complex with RAC3 | x-ray diffraction | A | — | 8 (best 0.76) |
| 6TM1 | Crystal structure of the DHR2 domain of DOCK10 in complex with RAC3 | x-ray diffraction | A | — | 8 (best 0.76) |
| P60763 | AlphaFold monomer V2.0 prediction for RAS-related C3 botulinum toxin substrate 3 (P60763) | predicted | A | — | 1 (best 0.51) |
Ligands
- MG · Magnesium ion · in 10 records
- CL · Chloride ion · in 6 records
- GDP · Guanosine-5'-diphosphate · in 6 records
- GCP · Phosphomethylphosphonic acid guanylate ester · in 4 records
- CA · Calcium ion · in 2 records
- GNP · Phosphoaminophosphonic acid-guanylate ester · in 2 records
- SO4 · Sulfate ion · in 2 records
Experiment against prediction
- 2C2H chain A against the predicted model P60763: TM-score 0.99, RMSD 0.61 Å
- 2C2H chain A against the predicted model P60763: TM-score 0.99, RMSD 0.61 Å
- 2QME chain A against the predicted model P60763: TM-score 0.98, RMSD 0.72 Å
- 2QME chain A against the predicted model P60763: TM-score 0.98, RMSD 0.72 Å
- 2OV2 chain A against the predicted model P60763: TM-score 0.98, RMSD 0.76 Å
- 2OV2 chain A against the predicted model P60763: TM-score 0.98, RMSD 0.76 Å
- 2OV2 chain E against the predicted model P60763: TM-score 0.98, RMSD 0.75 Å
- 2OV2 chain E against the predicted model P60763: TM-score 0.98, RMSD 0.75 Å
- 2C2H chain B against the predicted model P60763: TM-score 0.98, RMSD 0.88 Å
- 2C2H chain B against the predicted model P60763: TM-score 0.98, RMSD 0.88 Å
Elsewhere
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