Crystal structure of human RAC3 in complex with crib domain of human P21-activated kinase 1 (PAK1)

Structure

x-ray diffraction · 2 distinct chains · 34% helix, 29% strand (DSSP).

Ligands and binding sites

• GCP · Phosphomethylphosphonic acid guanylate ester · ligand · chains A
• MG · Magnesium ion · metal · chains A
• GOL · Glycerol · additive · 2 copies · chains A, I

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–I · 885 Ų buried · 23 hydrogen bonds · protein-protein

Compared structures

• 2QME · Crystal structure of human RAC3 in complex with CRIB domain of human p21-activated kinase… · the same entry in another collection · chain A against A, TM-score 1.00
• P60763 · AlphaFold monomer V2.0 prediction for RAS-related C3 botulinum toxin substrate 3 (P60763) · a predicted model of the same protein · chain A against A, TM-score 0.98
• Q13153 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase pak 1 (Q13153) · a predicted model of the same protein · chain I against A, TM-score 0.21

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P60763
• Every structure of UniProt Q13153
• Elsewhere: RCSB PDB 2QME · PDBe 2QME · UniProt P60763 · UniProt Q13153