MolNFT v1 · #32845 · protein
Crystal structure of the human RAC3 in complex with GDP
2C2H · RAS-related C3 botulinum toxin substrate 3: “Crystal structure of the human RAC3 in complex with GDP”. X-ray diffraction, 4 ligands (GDP, CA, MG), 1 pocket (best druggability 0.45). MolNFT v1 #32845 on GenesisL1: 3D structure…
- PDB
- 2C2H
- Type
- protein
- Length
- 341 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RAS-related C3 botulinum toxin substrate 3
- UniProt
- P60763
- Ligands
- GDP, CA, MG, SO4
- Pockets
- 1 · best druggability 0.45
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RAS-related C3 botulinum toxin substrate 3 | protein | 168 | 41% helix, 23% strand | P60763 |
| B | RAS-related C3 botulinum toxin substrate 3 | protein | 173 | 40% helix, 24% strand | P60763 |
Ligands and binding sites
- GDP · Guanosine-5'-diphosphate · ligand · 9 copies · chains A, B
- CA · Calcium ion · metal · 12 copies · chains A, B
- MG · Magnesium ion · metal · 5 copies · chains A, B
- SO4 · Sulfate ion · ion · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 183 | 0.45 | 0.74 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 194 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 2C2H · Crystal structure of the human RAC3 in complex with GDP · the same entry in another collection · chain A against A, TM-score 1.00
- P60763 · AlphaFold monomer V2.0 prediction for RAS-related C3 botulinum toxin substrate 3 (P60763) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P60763
- Elsewhere: RCSB PDB 2C2H · PDBe 2C2H · UniProt P60763
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.