MolNFT v1 · #37416 · protein
The crystal structure of the human RAC3 in complex with GDP and chloride
2G0N · RAS-related C3 botulinum toxin substrate 3: “The crystal structure of the human RAC3 in complex with GDP and chloride”. X-ray diffraction, 3 ligands (GDP, MG, CL), 1 pocket (best druggability 0.79). MolNFT v1 #37416 on GenesisL1: 3D…
- PDB
- 2G0N
- Type
- protein
- Length
- 357 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RAS-related C3 botulinum toxin substrate 3
- UniProt
- P60763
- Ligands
- GDP, MG, CL
- Pockets
- 1 · best druggability 0.79
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RAS-related C3 botulinum toxin substrate 3 | protein | 179 | 39% helix, 23% strand | P60763 |
| B | RAS-related C3 botulinum toxin substrate 3 | protein | 178 | 39% helix, 24% strand | P60763 |
Ligands and binding sites
- GDP · Guanosine-5'-diphosphate · ligand · 2 copies · chains A, B
- MG · Magnesium ion · metal · 2 copies · chains A, B
- CL · Chloride ion · ion · 3 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1031 | 0.79 | 0.81 | 83 | MG, CL, GDP |
Interfaces
1 interface between chains.
- A–B · 842 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 2G0N · The Crystal Structure of the Human RAC3 in complex with GDP and Chloride · the same entry in another collection · chain A against A, TM-score 1.00
- P60763 · AlphaFold monomer V2.0 prediction for RAS-related C3 botulinum toxin substrate 3 (P60763) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P60763
- Elsewhere: RCSB PDB 2G0N · PDBe 2G0N · UniProt P60763
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