Crystal structure of human RAC3 grown in the presence of GPP(NH)P.

Structure

x-ray diffraction · 2 distinct chains · 39% helix, 24% strand (DSSP).

Ligands and binding sites

• GNP · Phosphoaminophosphonic acid-guanylate ester · ligand · chains A, B
• GDP · Guanosine-5'-diphosphate · ligand · chains A, B
• MG · Magnesium ion · metal · 2 copies · chains A, B
• CL · Chloride ion · ion · 2 copies · chains A, B
• BTB · 2-[bis-(2-hydroxy-ethyl)-amino]-2-hydroxymethyl-propane-1,3-diol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 797 Ų buried · 12 hydrogen bonds · protein-protein

Compared structures

• 2IC5 · Crystal structure of human RAC3 grown in the presence of Gpp(NH)p. · the same entry in another collection · chain A against A, TM-score 1.00
• P60763 · AlphaFold monomer V2.0 prediction for RAS-related C3 botulinum toxin substrate 3 (P60763) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P60763
• Elsewhere: RCSB PDB 2IC5 · PDBe 2IC5 · UniProt P60763