UniProt P40348
Replication factor C subunit 2 (P40348)
Replication factor C subunit 2 (UniProt P40348): 46 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 164 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P40348
- Protein
- Replication factor C subunit 2
- Experimental structures
- 46
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 164 · 20 records with a druggable one
Structures
47 records of P40348 in the MolNFT archive: 46 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1SXJ | Crystal Structure of the Eukaryotic Clamp Loader (Replication Factor C, RFC) Bound to the DNA… | x-ray diffraction | D | — | — |
| 1SXJ | Crystal structure of the eukaryotic clamp loader (replication factor C, rfc) bound to the DNA… | x-ray diffraction | D | — | — |
| 7SGZ | Structure of the yeast Rad24-RFC loader bound to DNA and the closed 9-1-1 clamp | electron microscopy | D | AGS, MG | 7 (best 0.86) |
| 7SGZ | Structure of the yeast RAD24-rfc loader bound to DNA and the closed 9- 1-1 clamp | electron microscopy | D | AGS, MG | — |
| 7SH2 | Structure of the yeast RAD24-rfc loader bound to DNA and the open 9-1- 1 clamp | electron microscopy | D | AGS, MG | — |
| 7ST9 | Open state of RAD24-RFC:9-1-1 bound to a 5' SS/DSDNA junction | electron microscopy | D | AGS, MG | — |
| 7STB | Closed state of Rad24-RFC:9-1-1 bound to a 5' ss/dsDNA junction | electron microscopy | D | MG, AGS | 8 (best 0.82) |
| 7STB | Closed state of RAD24-RFC:9-1-1 bound to a 5' SS/DSDNA junction | electron microscopy | D | MG, AGS | — |
| 7STE | RAD24-rfc ADP state | electron microscopy | D | ADP | — |
| 7TFJ | Atomic model of S. cerevisiae clamp-clamp loader complex PCNA-RFC bound to DNA with a closed clamp… | electron microscopy | D | AGS, MG | 9 (best 0.85) |
| 7THJ | Structure of the yeast clamp loader (replication factor C rfc) bound to the sliding clamp… | electron microscopy | D | AGS, MG | — |
| 7THV | Structure of the yeast clamp loader (replication factor C rfc) bound to the sliding clamp… | electron microscopy | D | AGS, MG | — |
| 7TI8 | Structure of the yeast clamp loader (replication factor C rfc) bound to the open sliding clamp… | electron microscopy | D | AGS, MG | — |
| 7TIB | Structure of the yeast clamp loader (replication factor C rfc) bound to the open sliding clamp… | electron microscopy | D | AGS, MG | — |
| 7TIC | Structure of the yeast clamp loader (replication factor C rfc) bound to the sliding clamp… | electron microscopy | D | AGS, MG | — |
| 7TID | Structure of the yeast clamp loader (Replication Factor C RFC) bound to the sliding clamp… | electron microscopy | D | AGS, MG | 10 (best 0.88) |
| 7TID | Structure of the yeast clamp loader (replication factor C rfc) bound to the sliding clamp… | electron microscopy | D | AGS, MG | — |
| 7TKU | Structure of the yeast clamp loader (Replication Factor C RFC) bound to the open sliding clamp… | electron microscopy | D | AGS, MG | 9 (best 0.84) |
| 7TKU | Structure of the yeast clamp loader (replication factor C rfc) bound to the open sliding clamp… | electron microscopy | D | AGS, MG | — |
| 7U19 | RFC:PCNA bound to nicked DNA | electron microscopy | D | AGS, MG | — |
| 7U1A | RFC:PCNA bound to dsDNA with a ssDNA gap of six nucleotides | electron microscopy | D | AGS, MG | 8 (best 0.87) |
| 7U1A | RFC:PCNA bound to dsdna with a ssdna gap of six nucleotides | electron microscopy | D | AGS, MG | — |
| 7U1P | RFC:PCNA bound to DNA with a ssDNA gap of five nucleotides | electron microscopy | D | AGS, MG | 9 (best 0.88) |
| 7U1P | RFC:PCNA bound to DNA with a ssdna gap of five nucleotides | electron microscopy | D | AGS, MG | — |
| 8DQW | Open state of Rad24-RFC:9-1-1 bound to a 5' ss/dsDNA junction | electron microscopy | D | MG, AGS | 7 (best 0.82) |
| 8DQW | Open state of RAD24-RFC:9-1-1 bound to a 5' SS/DSDNA junction | electron microscopy | D | AGS, MG | — |
| 8DQX | Open state of RFC:PCNA bound to a 3' ss/dsDNA junction | electron microscopy | D | MG, AGS | 10 (best 0.85) |
| 8DQX | Open state of RFC:PCNA bound to a 3' SS/DSDNA junction | electron microscopy | D | AGS, MG | — |
| 8DQZ | Intermediate state of RFC:PCNA bound to a 3' SS/DSDNA junction | electron microscopy | D | MG, AGS | — |
| 8DR0 | Closed state of RFC:PCNA bound to a 3' ss/dsDNA junction | electron microscopy | D | MG, AGS | 10 (best 0.84) |
| 8DR0 | Closed state of RFC:PCNA bound to a 3' SS/DSDNA junction | electron microscopy | D | MG, AGS | — |
| 8DR1 | Consensus closed state of RFC:PCNA bound to a 3' SS/DSDNA junction (DNA2) | electron microscopy | D | AGS, MG | — |
| 8DR3 | Closed state of RFC:PCNA bound to a 3' ss/dsDNA junction (DNA2) with NTD | electron microscopy | D | MG, AGS | 10 (best 0.82) |
| 8DR3 | Closed state of RFC:PCNA bound to a 3' SS/DSDNA junction (DNA2) with ntd | electron microscopy | D | AGS, MG | — |
| 8DR4 | Open state of RFC:PCNA bound to a 3' SS/DSDNA junction (DNA2) without ntd | electron microscopy | D | AGS, MG | — |
| 8DR5 | Open state of RFC:PCNA bound to a 3' SS/DSDNA junction (DNA2) with ntd | electron microscopy | D | AGS, MG | — |
| 8DR6 | Closed state of RFC:PCNA bound to a nicked dsdna | electron microscopy | D | MG, AGS | — |
| 8DR7 | Open state of RFC:PCNA bound to a nicked dsDNA | electron microscopy | D | MG, AGS | 9 (best 0.86) |
| 8DR7 | Open state of RFC:PCNA bound to a nicked dsdna | electron microscopy | D | MG, AGS | — |
| 8FS4 | Structure of S. cerevisiae Rad24-RFC loading the 9-1-1 clamp onto a 10-nt gapped DNA in step 2… | electron microscopy | D | AGS, MG | 8 (best 0.86) |
| 8FS6 | Structure of S. cerevisiae Rad24-RFC loading the 9-1-1 clamp onto a 10-nt gapped DNA in step 4… | electron microscopy | D | AGS, MG | 7 (best 0.82) |
| 8THB | Structure of the Saccharomyces cerevisiae PCNA clamp unloader Elg1-RFC complex | electron microscopy | D | AGS, MG | 10 (best 0.87) |
| 8THC | Structure of the Saccharomyces cerevisiae clamp unloader Elg1-RFC bound to a cracked PCNA | electron microscopy | D | AGS, MG | 8 (best 0.88) |
| 8THD | Structure of the Saccharomyces cerevisiae clamp unloader Elg1-RFC bound to PCNA | electron microscopy | D | AGS, MG | 8 (best 0.85) |
| 8TW7 | Cryo-EM structure of S. cerevisiae Ctf18-RFC-PCNA complex in Apo state conformation I | electron microscopy | 2 | AGS, MG | 7 (best 0.84) |
| 8TWA | Cryo-EM structure of S. cerevisiae Ctf18-RFC-PCNA-PolE-DNA complex | electron microscopy | 2 | AGS, MG | 8 (best 0.86) |
| P40348 | AlphaFold monomer V2.0 prediction for replication factor C subunit 2 (P40348) | predicted | A | — | 2 (best 0.67) |
Ligands
Experiment against prediction
- 1SXJ chain D against the predicted model P40348: TM-score 0.97, RMSD 1.25 Å
- 1SXJ chain D against the predicted model P40348: TM-score 0.97, RMSD 1.25 Å
- 7THV chain D against the predicted model P40348: TM-score 0.96, RMSD 1.33 Å
- 8DQX chain D against the predicted model P40348: TM-score 0.96, RMSD 1.36 Å
- 8DQX chain D against the predicted model P40348: TM-score 0.96, RMSD 1.36 Å
- 8DR4 chain D against the predicted model P40348: TM-score 0.96, RMSD 1.40 Å
- 8DR5 chain D against the predicted model P40348: TM-score 0.96, RMSD 1.40 Å
- 8FS4 chain D against the predicted model P40348: TM-score 0.96, RMSD 1.40 Å
- 8FS6 chain D against the predicted model P40348: TM-score 0.96, RMSD 1.41 Å
- 7STB chain D against the predicted model P40348: TM-score 0.96, RMSD 1.42 Å
Elsewhere
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