MolNFT v1 · #341112 · protein
AlphaFold monomer V2.0 prediction for replication factor C subunit 2 (P40348)
P40348: “AlphaFold monomer V2.0 prediction for replication factor C subunit 2 (P40348)”. 2 pockets (best druggability 0.67). MolNFT v1 #341112 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P40348
- Type
- protein
- Length
- 353 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x9DC039DF1aC938C188D9b20e6591d287429437BF
- Molecule
- Replication factor C subunit 2
- UniProt
- P40348
- Pockets
- 2 · best druggability 0.67
Structure
1 distinct chain · 62% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Replication factor C subunit 2 | protein | 353 | 62% helix, 8% strand | P40348 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 152 | 0.67 | 0.88 | 29 | empty |
| 2 | 74 | 0.30 | 0.74 | 16 | empty |
Compared structures
- 8DR0 · Closed state of RFC:PCNA bound to a 3' SS/DSDNA junction · an experimental structure of the same protein · chain A against D, TM-score 0.92
- 8DR1 · Consensus closed state of RFC:PCNA bound to a 3' SS/DSDNA junction (DNA2) · an experimental structure of the same protein · chain A against D, TM-score 0.92
- 8DR6 · Closed state of RFC:PCNA bound to a nicked dsdna · an experimental structure of the same protein · chain A against D, TM-score 0.92
- 8DR3 · Closed state of RFC:PCNA bound to a 3' SS/DSDNA junction (DNA2) with ntd · an experimental structure of the same protein · chain A against D, TM-score 0.92
- 7U1P · RFC:PCNA bound to DNA with a ssdna gap of five nucleotides · an experimental structure of the same protein · chain A against D, TM-score 0.91
- 7TIB · Structure of the yeast clamp loader (replication factor C rfc) bound to the open sliding… · an experimental structure of the same protein · chain A against D, TM-score 0.91
- 7U19 · RFC:PCNA bound to nicked DNA · an experimental structure of the same protein · chain A against D, TM-score 0.91
- 7TID · Structure of the yeast clamp loader (replication factor C rfc) bound to the sliding clamp… · an experimental structure of the same protein · chain A against D, TM-score 0.91
- 7U1A · RFC:PCNA bound to dsdna with a ssdna gap of six nucleotides · an experimental structure of the same protein · chain A against D, TM-score 0.91
- 7TI8 · Structure of the yeast clamp loader (replication factor C rfc) bound to the open sliding… · an experimental structure of the same protein · chain A against D, TM-score 0.91
- 8DQZ · Intermediate state of RFC:PCNA bound to a 3' SS/DSDNA junction · an experimental structure of the same protein · chain A against D, TM-score 0.91
- 7ST9 · Open state of RAD24-RFC:9-1-1 bound to a 5' SS/DSDNA junction · an experimental structure of the same protein · chain A against D, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P40348
- Elsewhere: UniProt P40348 · AlphaFold DB P40348
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