UniProt P38251
Replication factor C subunit 5 (P38251)
Replication factor C subunit 5 (UniProt P38251): 31 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 34 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P38251
- Protein
- Replication factor C subunit 5
- Experimental structures
- 31
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 34 · 5 records with a druggable one
Structures
32 records of P38251 in the MolNFT archive: 31 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1SXJ | Crystal Structure of the Eukaryotic Clamp Loader (Replication Factor C, RFC) Bound to the DNA… | x-ray diffraction | E | — | — |
| 1SXJ | Crystal structure of the eukaryotic clamp loader (replication factor C, rfc) bound to the DNA… | x-ray diffraction | E | — | — |
| 7SGZ | Structure of the yeast RAD24-rfc loader bound to DNA and the closed 9- 1-1 clamp | electron microscopy | E | AGS, MG, ADP, PO4 | — |
| 7SH2 | Structure of the yeast RAD24-rfc loader bound to DNA and the open 9-1- 1 clamp | electron microscopy | E | AGS, MG, ADP | — |
| 7ST9 | Open state of RAD24-RFC:9-1-1 bound to a 5' SS/DSDNA junction | electron microscopy | E | MG, AGS, ADP | — |
| 7STB | Closed state of RAD24-RFC:9-1-1 bound to a 5' SS/DSDNA junction | electron microscopy | E | MG, AGS, ADP | — |
| 7STE | RAD24-rfc ADP state | electron microscopy | E | ADP | — |
| 7THJ | Structure of the yeast clamp loader (replication factor C rfc) bound to the sliding clamp… | electron microscopy | E | AGS, ADP | — |
| 7THV | Structure of the yeast clamp loader (replication factor C rfc) bound to the sliding clamp… | electron microscopy | E | AGS, ADP | — |
| 7TI8 | Structure of the yeast clamp loader (replication factor C rfc) bound to the open sliding clamp… | electron microscopy | E | AGS, ADP | — |
| 7TIB | Structure of the yeast clamp loader (replication factor C rfc) bound to the open sliding clamp… | electron microscopy | E | AGS, MG, ADP | — |
| 7TIC | Structure of the yeast clamp loader (replication factor C rfc) bound to the sliding clamp… | electron microscopy | E | AGS, ADP | — |
| 7TID | Structure of the yeast clamp loader (replication factor C rfc) bound to the sliding clamp… | electron microscopy | E | AGS, MG, ADP | — |
| 7TKU | Structure of the yeast clamp loader (replication factor C rfc) bound to the open sliding clamp… | electron microscopy | E | AGS, ADP | — |
| 7U19 | RFC:PCNA bound to nicked DNA | electron microscopy | E | AGS, ADP | — |
| 7U1A | RFC:PCNA bound to dsdna with a ssdna gap of six nucleotides | electron microscopy | E | AGS, ADP | — |
| 7U1P | RFC:PCNA bound to DNA with a ssdna gap of five nucleotides | electron microscopy | E | AGS, MG, ADP | — |
| 8DQW | Open state of Rad24-RFC:9-1-1 bound to a 5' ss/dsDNA junction | electron microscopy | E | MG, AGS, GDP | 8 (best 0.84) |
| 8DQW | Open state of RAD24-RFC:9-1-1 bound to a 5' SS/DSDNA junction | electron microscopy | E | MG, AGS, GDP | — |
| 8DQX | Open state of RFC:PCNA bound to a 3' SS/DSDNA junction | electron microscopy | E | MG, AGS, GDP | — |
| 8DQZ | Intermediate state of RFC:PCNA bound to a 3' SS/DSDNA junction | electron microscopy | E | MG, AGS, GDP | — |
| 8DR0 | Closed state of RFC:PCNA bound to a 3' ss/dsDNA junction | electron microscopy | E | MG, AGS, GDP | 7 (best 0.83) |
| 8DR0 | Closed state of RFC:PCNA bound to a 3' SS/DSDNA junction | electron microscopy | E | AGS, GDP | — |
| 8DR1 | Consensus closed state of RFC:PCNA bound to a 3' SS/DSDNA junction (DNA2) | electron microscopy | E | AGS, GDP | — |
| 8DR3 | Closed state of RFC:PCNA bound to a 3' SS/DSDNA junction (DNA2) with ntd | electron microscopy | E | MG, AGS, GDP | — |
| 8DR4 | Open state of RFC:PCNA bound to a 3' SS/DSDNA junction (DNA2) without ntd | electron microscopy | E | AGS, GDP | — |
| 8DR5 | Open state of RFC:PCNA bound to a 3' SS/DSDNA junction (DNA2) with ntd | electron microscopy | E | MG, AGS, GDP | — |
| 8DR6 | Closed state of RFC:PCNA bound to a nicked dsdna | electron microscopy | E | MG, AGS, ADP | — |
| 8DR7 | Open state of RFC:PCNA bound to a nicked dsdna | electron microscopy | E | MG, AGS, GDP | — |
| 8THB | Structure of the Saccharomyces cerevisiae PCNA clamp unloader Elg1-RFC complex | electron microscopy | E | AGS, ADP | 10 (best 0.87) |
| 8THC | Structure of the Saccharomyces cerevisiae clamp unloader Elg1-RFC bound to a cracked PCNA | electron microscopy | E | ADP | 6 (best 0.88) |
| P38251 | AlphaFold monomer V2.0 prediction for replication factor C subunit 5 (P38251) | predicted | A | — | 3 (best 0.64) |
Ligands
Experiment against prediction
- 7STE chain E against the predicted model P38251: TM-score 0.99, RMSD 0.81 Å
- 1SXJ chain E against the predicted model P38251: TM-score 0.98, RMSD 0.99 Å
- 1SXJ chain E against the predicted model P38251: TM-score 0.98, RMSD 0.99 Å
- 7THV chain E against the predicted model P38251: TM-score 0.98, RMSD 1.08 Å
- 8THB chain E against the predicted model P38251: TM-score 0.97, RMSD 1.22 Å
- 7THJ chain E against the predicted model P38251: TM-score 0.97, RMSD 1.19 Å
- 8THC chain E against the predicted model P38251: TM-score 0.97, RMSD 1.28 Å
- 7TIC chain E against the predicted model P38251: TM-score 0.96, RMSD 1.35 Å
- 7U19 chain E against the predicted model P38251: TM-score 0.96, RMSD 1.35 Å
- 7TID chain E against the predicted model P38251: TM-score 0.96, RMSD 1.37 Å
Elsewhere
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