UniProt P34897
Serine hydroxymethyltransferase, mitochondrial (P34897)
Serine hydroxymethyltransferase, mitochondrial (UniProt P34897), EC 2.1.2.1: 20 experimental structures and 1 predicted model on GenesisL1, 16 ligands bound, 56 pockets. Binding sites, druggability and experiment against…
- UniProt
- P34897
- Protein
- Serine hydroxymethyltransferase, mitochondrial
- EC
- 2.1.2.1
- Experimental structures
- 20
- Predicted models
- 1
- Ligands
- 16
- Pockets
- 56 · 5 records with a druggable one
Structures
21 records of P34897 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4PVF | Crystal structure of Homo sapiens holo serine hydroxymethyltransferase 2 (mitochondrial) (SHMT2)… | x-ray diffraction | A, B | — | — |
| 4PVF | Crystal structure of homo sapiens holo serine hydroxymethyltransferase 2 (mitochondrial) (SHMT2)… | x-ray diffraction | A, B | — | — |
| 5V7I | Crystal structure of homo sapiens serine hydroxymethyltransferase 2 (mitochondrial) (SHMT2), in… | x-ray diffraction | A, B | 8Z1 | — |
| 5X3V | Structure of human SHMT2 protein mutant | x-ray diffraction | A, B | SO4 | — |
| 6DK3 | HUMAN MITOCHONDRIAL SERINE HYDROXYMETHYLTRANSFERASe 2 | x-ray diffraction | A | UNX | — |
| 6DK3 | Human mitochondrial serine hydroxymethyltransferase 2 | x-ray diffraction | A | UNX | — |
| 6H3C | Cryo-EM structure of the BRISC complex bound to SHMT2 | electron microscopy | E, J | — | — |
| 6H3C | Cryo-EM structure of the brisc complex bound to SHMT2 | electron microscopy | E, J | — | — |
| 6M5O | Co-crystal structure of human serine hydroxymethyltransferase 2 in complex with pyridoxal… | x-ray diffraction | A, B | DXC | — |
| 6QVG | Human SHMT2 in complex with lometrexol | x-ray diffraction | A, B | NA, PLP | — |
| 6QVG | Human SHMT2 in complex with lometrexol | x-ray diffraction | A, B | NA, PLP | — |
| 6QVL | Human SHMT2 in complex with pemetrexed | x-ray diffraction | A, B | CA, PLP, 4DW | — |
| 6QVL | Human SHMT2 in complex with pemetrexed | x-ray diffraction | A, B | CA, PLP, 4DW | — |
| 6R8F | Cryo-EM structure of the human brisc-SHMT2 complex | electron microscopy | K, L | — | — |
| 7BYI | Structure of SHMT2 in complex with cbx | x-ray diffraction | A, B | PO4, CBO | — |
| 8GKW | Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and AGF359… | x-ray diffraction | A, B | GLY, PLP, ZVR | 8 (best 0.73) |
| 8GKY | Human mitochondrial serine hydroxymethyltransferase (SHMT2) Y105F in complex with PLP, glycine and… | x-ray diffraction | A, B | ZVR, GLY, PLP | 9 (best 0.73) |
| 8SSJ | Room-temperature X-ray structure of human mitochondrial serine hydroxymethyltransferase (hSHMT2) | x-ray diffraction | A, B | CL | 12 (best 0.73) |
| 8T4O | Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and AGF347… | x-ray diffraction | A, B | Y5C, PLG | 14 (best 0.74) |
| 8TLC | Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and… | x-ray diffraction | A, B | I6I | 13 (best 0.73) |
| P34897 | AlphaFold monomer V2.0 prediction for serine hydroxymethyltransferase, mitochondrial (P34897) | predicted | A | — | — |
Ligands
- PLP · Pyridoxal-5'-phosphate · in 6 records
- 4DW · N-{4-[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamic acid · in 2 records
- CA · Calcium ion · in 2 records
- GLY · Glycine · in 2 records
- NA · Sodium ion · in 2 records
- UNX · Unknown atom or ion · in 2 records
- ZVR · N-{4-[3-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)propyl]-2-fluorobenzoyl}-L-glutamic acid · in 2 records
- 8Z1 · (4R)-6-amino-3-methyl-4-(propan-2-yl)-4-[3-(pyrrolidin-1-yl)-5-(trifluoromethyl)phenyl]-1,4-dihydropyrano[2, 3-c]pyrazole-5-carbonitrile · in 1 record
- CBO · Carbenoxolone · in 1 record
- CL · Chloride ion · in 1 record
- DXC · (3alpha,5beta,12alpha)-3,12-dihydroxycholan-24-oic acid · in 1 record
- I6I · N-{4-[4-(2-amino-4-oxo-1,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl}-D-gamma-glutamyl-L-gamma-glutamyl-D-glutamic acid · in 1 record
- PLG · N-glycine-[3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-yl-methane] · in 1 record
- PO4 · Phosphate ion · in 1 record
- SO4 · Sulfate ion · in 1 record
- Y5C · 4-[4-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoic acid · in 1 record
Experiment against prediction
- 8SSJ chain A against the predicted model P34897: TM-score 1.00, RMSD 0.37 Å
- 4PVF chain B against the predicted model P34897: TM-score 1.00, RMSD 0.42 Å
- 4PVF chain B against the predicted model P34897: TM-score 1.00, RMSD 0.42 Å
- 8SSJ chain B against the predicted model P34897: TM-score 1.00, RMSD 0.44 Å
- 8GKW chain A against the predicted model P34897: TM-score 1.00, RMSD 0.47 Å
- 8T4O chain A against the predicted model P34897: TM-score 1.00, RMSD 0.46 Å
- 5V7I chain A against the predicted model P34897: TM-score 1.00, RMSD 0.50 Å
- 8GKW chain B against the predicted model P34897: TM-score 1.00, RMSD 0.49 Å
- 6QVL chain A against the predicted model P34897: TM-score 1.00, RMSD 0.52 Å
- 6QVL chain A against the predicted model P34897: TM-score 1.00, RMSD 0.52 Å
Elsewhere
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