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Ligand · ZVR

ZVR · N-{4-[3-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)propyl]-2-fluorobenzoyl}-L-glutamic acid

ZVR, N-{4-[3-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)propyl]-2-fluorobenzoyl}-L-glutamic acid (C21 H22 F N5 O6, 459.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (2 PDB entries). Every binding site…

Component
ZVR
Formula
C21 H22 F N5 O6
Class
ligand
Structures
2
PDB entries
2

Binding sites

ZVR in 2 structures; the first of them:

  • 8GKW · Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine… · ZVR B701 · binds LEU166, GLY169, GLY170, HIS171, LEU172, TYR176, ILE183, SER226 and 11 more
  • 8GKY · Human mitochondrial serine hydroxymethyltransferase (SHMT2) Y105F in complex with PLP… · ZVR A601 · binds LEU166, GLY169, GLY170, HIS171, LEU172, TYR176, SER178, VAL180 and 12 more

Residues it binds most

PHE 3, TYR 3, GLY 3, LEU 3, ASN 3, SER 3, LYS 3, ALA 3, ARG 3, GLU 3 (residue and the binding sites it lines).

Found with

  • GLY · Glycine
  • PLP · Pyridoxal-5'-phosphate

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