GL1X · GenesisL1 explorer

Ligand · Y79

Y79 · N-{4-[4-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl}-L-glutamic acid

Y79, N-{4-[4-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl}-L-glutamic acid (C22 H24 F N5 O6, 473.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (2 PDB entries). Every binding site…

Component
Y79
Formula
C22 H24 F N5 O6
Class
ligand
Structures
2
PDB entries
2

Binding sites

Y79 in 2 structures; the first of them:

  • 8FJU · Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine… · Y79 A602 · binds LEU166, GLY169, GLY170, HIS171, LEU172, TYR176, VAL180, LYS181 and 11 more
  • 8FJW · Human GAR transformylase in complex with GAR substrate and AGF347 inhibitor · Y79 A1102 · binds ARG871, LEU892, PHE895, MET896, ARG897, ILE898, LEU899, VAL904 and 8 more

Residues it binds most

LEU 3, TYR 2, GLY 3, PHE 3, ALA 3, ARG 3, ASN 3, SER 3, VAL 2, GLU 3 (residue and the binding sites it lines).

Found with

  • GAR · Glycinamide ribonucleotide
  • PLG · N-glycine-[3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-yl-methane]

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