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Ligand · PLG

PLG · N-glycine-[3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-yl-methane]

PLG, N-glycine-[3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-yl-methane] (C10 H15 N2 O7 P, 306.2 g/mol), in the MolNFT structures on GenesisL1: bound in 29 records (29 PDB entries). Every binding site with its residues within 4.5 Å…

Component
PLG
Formula
C10 H15 N2 O7 P
Class
ligand
Structures
29
PDB entries
29

Binding sites

PLG in 29 structures; the first of them:

  • 5GVK · Plasmodium vivax SHMT bound with PLP-glycine and GS256 · PLG A501 · binds SER34, SER100, GLY101, SER102, ASN105, HIS129, HIS132, TYR182 and 13 more
  • 5GVM · Plasmodium vivax SHMT bound with PLP-glycine and GS557 · PLG A501 · binds SER34, SER100, GLY101, SER102, ASN105, HIS129, THR131, HIS132 and 14 more
  • 5GVP · Plasmodium vivax SHMT bound with PLP-glycine and GS654 · PLG A501 · binds SER34, SER100, GLY101, SER102, ASN105, HIS129, THR131, HIS132 and 14 more
  • 5XMP · Plasmodium vivax SHMT(C346A) bound with PLP-glycine and MF057 · PLG A501 · binds SER34, SER100, GLY101, SER102, ASN105, HIS129, THR131, HIS132 and 14 more
  • 5XMQ · Plasmodium vivax SHMT(C346A) bound with PLP-glycine and MF011 · PLG A501 · binds SER34, SER100, GLY101, SER102, ASN105, HIS129, THR131, HIS132 and 14 more
  • 5XMS · Plasmodium vivax SHMT bound with PLP-glycine and GS498 · PLG A501 · binds SER34, SER100, GLY101, SER102, ASN105, HIS129, THR131, HIS132 and 14 more
  • 5XMT · Plasmodium vivax SHMT bound with PLP-glycine and GS380 · PLG A501 · binds SER34, SER100, GLY101, SER102, ASN105, HIS129, TYR182, THR183 and 12 more
  • 5XMU · Plasmodium vivax SHMT bound with PLP-glycine and GS363 · PLG A501 · binds SER34, SER100, GLY101, SER102, ASN105, HIS129, THR131, HIS132 and 14 more
  • 5XMV · Plasmodium vivax SHMT bound with PLP-glycine and GS362 · PLG A501 · binds SER34, SER100, GLY101, SER102, ASN105, HIS129, HIS132, TYR182 and 13 more
  • 5YFY · Plasmodium vivax SHMT bound with PLP-glycine and GS625 · PLG A501 · binds SER34, SER100, GLY101, SER102, ASN105, HIS129, HIS132, TYR182 and 13 more
  • 5YG0 · Plasmodium vivax SHMT bound with PLP-glycine and GS657 · PLG A501 · binds SER34, SER100, GLY101, SER102, ASN105, HIS129, THR131, HIS132 and 14 more
  • 5YG1 · Plasmodium vivax SHMT bound with PLP-glycine and GS704 · PLG A501 · binds SER34, SER100, GLY101, SER102, ASN105, HIS129, THR131, HIS132 and 14 more
  • 5YG2 · Plasmodium vivax SHMT bound with PLP-glycine and GS705 · PLG A501 · binds SER34, SER100, GLY101, SER102, ASN105, HIS129, THR131, HIS132 and 14 more
  • 5YG3 · Plasmodium vivax SHMT bound with PLP-glycine and S-GS834 · PLG A501 · binds SER34, SER100, GLY101, SER102, ASN105, HIS129, THR131, HIS132 and 14 more

Residues it binds most

SER 78, HIS 80, THR 80, GLY 76, TYR 71, ASN 80, ARG 75, ASP 78, LYS 72, ALA 38 (residue and the binding sites it lines).

Found with

  • CL · Chloride ion
  • EDO · 1,2-ethanediol
  • PLP · Pyridoxal-5'-phosphate
  • GOL · Glycerol
  • PEG · Di(hydroxyethyl)ether
  • 8A0 · (4~{S})-6-azanyl-3-methyl-4-[3-(2-methylphenyl)-5-(trifluoromethyl)phenyl]-4-propan-2-yl-2~{H}-pyrano[2, 3-c]pyrazole-5-carbonitrile
  • 8A3 · 4-[3-[(4~{S})-6-azanyl-5-cyano-3-methyl-4-propan-2-yl-2~{H}-pyrano[2,3-c]pyrazol-4-yl]-5-(trifluoromethyl) phenyl]-~{N}-methyl-~{N}-[2,2,2-tris(fluoranyl) ethyl]benzenesulfonamide
  • 8A6 · 4-[3-[(4~{S})-6-azanyl-5-cyano-3-methyl-4-propan-2-yl-2~{H}-pyrano[2,3-c]pyrazol-4-yl]-5-(trifluoromethyl) phenyl]-~{N}-methyl-~{N}-(phenylmethyl) benzenesulfonamide
  • 8AU · (4~{S})-6-azanyl-4-[3-(2-chlorophenyl)-5-(trifluoromethyl)phenyl]-3-methyl-4-propan-2-yl-2~{H}-pyrano[2,3-c]pyrazole-5-carbonitrile
  • 8B0 · (4~{S})-6-azanyl-4-[3-(2-cyanophenyl)-5-(trifluoromethyl)phenyl]-3-methyl-4-propan-2-yl-2~{H}-pyrano[2,3-c]pyrazole-5-carbonitrile
  • 8B3 · (4~{S})-6-azanyl-4-[3-(2-fluorophenyl)-5-(trifluoromethyl)phenyl]-3-methyl-4-propan-2-yl-2~{H}-pyrano[2,3-c]pyrazole-5-carbonitrile
  • 8UC · (3~{S})-6'-azanyl-7-fluoranyl-2,2,3'-trimethyl-5-pyridin-4-yl-spiro[1~{H}-indene-3,4'-2~{H}-pyrano[2,3-c]pyrazole]-5'-carbonitrile

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