FFO · N-[4-({[(6S)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid

Binding sites

FFO in 5 structures; the first of them:

• 6R2E · Crystal structure of the human thymidylate synthase (hTS) interface variant Q62R · FFO A403 · binds PHE80, ILE108, TRP109, ASN112, LEU192, CME195, HIS196, ASP218 and 8 more
• 7TH4 · T. thermophilus methylenetetrahydrofolate reductase complex with 5-formyltetrahydrofolate · FFO A501 · binds GLU18, PHE20, LYS23, THR49, ASP109, GLN180, LEU181, MET209 and 8 more
• 8DSK · Structure of the N358Y variant of serine hydroxymethyltransferase 8 in complex with PLP… · FFO A502 · binds LEU129, GLY132, GLY133, HIS134, LEU135, TYR139, LYS145, ILE147 and 13 more
• 9BOW · X-ray structure of Thermus thermophilus serine hydroxymethyltransferase with PLP-L-Ser… · FFO B502 · binds GLU53, TYR60, TYR61, PHE252, PRO253, LEU117, GLY120, GLY121 and 11 more
• 9BPE · Joint X-ray/neutron structure of Thermus thermophilus serine hydroxymethyltransferase… · FFO B2001 · binds GLU53, TYR60, TYR61, PHE252, PRO253, LEU1117, GLY1120, GLY1121 and 12 more

Residues it binds most

LEU 16, TYR 16, PHE 16, ASN 14, GLY 14, ILE 12, ALA 14, HIS 14, ARG 8, GLU 12 (residue and the binding sites it lines).

Found with

• SO4 · Sulfate ion
• CL · Chloride ion
• ACT · Acetate ion
• FAD · Flavin-adenine dinucleotide
• KOU · (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-serine
• PLG · N-glycine-[3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-yl-methane]
• SER · Serine
• EDO · 1,2-ethanediol
• GOL · Glycerol