UniProt P23246
Splicing factor, proline- and glutamine-rich (P23246)
Splicing factor, proline- and glutamine-rich (UniProt P23246): 19 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 37 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P23246
- Protein
- Splicing factor, proline- and glutamine-rich
- Experimental structures
- 19
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 37 · 4 records with a druggable one
Structures
20 records of P23246 in the MolNFT archive: 19 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4WII | Human splicing factor, construct 3 | x-ray diffraction | A, B | — | — |
| 4WII | Human splicing factor, construct 3 | x-ray diffraction | A, B | — | — |
| 4WIJ | Human splicing factor, construct 1 | x-ray diffraction | A, B | — | — |
| 4WIJ | Human splicing factor, construct 1 | x-ray diffraction | A, B | — | — |
| 4WIK | Human splicing factor, construct 2 | x-ray diffraction | A, B | — | — |
| 4WIK | Human splicing factor, construct 2 | x-ray diffraction | A, B | — | — |
| 5WPA | Structure of human SFPQ/PSPC1 heterodimer | x-ray diffraction | A | — | — |
| 6NCQ | The dimerization domain of human sfpq in space group C2221 | x-ray diffraction | A | — | — |
| 6OWJ | Zn-mediated polymerization of human SFPQ | x-ray diffraction | A, B | ZN | 4 (best 0.77) |
| 6OWJ | Zn-mediated polymerization of human sfpq | x-ray diffraction | A, B | ZN | — |
| 6WMZ | Crystal structure of human SFPQ/NONO complex | x-ray diffraction | A, C | — | 15 (best 0.85) |
| 6WMZ | Crystal structure of human SFPQ/NONO complex | x-ray diffraction | A, C | — | — |
| 7LRQ | Crystal structure of human SFPQ/NONO heterodimer, conserved DBHS region | x-ray diffraction | A | CL | — |
| 7LRQ | Crystal structure of human SFPQ/NONO heterodimer, conserved dbhs region | x-ray diffraction | A | CL | — |
| 7LRU | Crystal structure of SFPQ-NONO-SFPQ chimeric protein homodimer | x-ray diffraction | B | — | 1 (best 0.42) |
| 7LRU | Crystal structure of sfpq-nono-sfpq chimeric protein homodimer | x-ray diffraction | B | — | — |
| 7PU5 | Structure of sfpq-nono complex | x-ray diffraction | B, D, F, H, J, L | MG | — |
| 7UJ1 | Crystal structure of PSF-RNA complex | x-ray diffraction | A, B | — | 7 (best 0.87) |
| 7UK1 | Complex Structure of Human Polypyrimidine Splicing Factor (PSF/SFPQ) with Murine Virus-like 30S… | x-ray diffraction | A, B | MG | 7 (best 0.72) |
| P23246 | AlphaFold monomer V2.0 prediction for splicing factor, proline- and glutamine-rich (P23246) | predicted | A | — | 3 (best 0.50) |
Ligands
Experiment against prediction
- 5WPA chain A against the predicted model P23246: TM-score 0.93, RMSD 1.64 Å
- 7LRU chain B against the predicted model P23246: TM-score 0.92, RMSD 1.87 Å
- 7LRU chain B against the predicted model P23246: TM-score 0.92, RMSD 1.87 Å
- 6OWJ chain A against the predicted model P23246: TM-score 0.92, RMSD 2.08 Å
- 6OWJ chain A against the predicted model P23246: TM-score 0.92, RMSD 2.08 Å
- 7UK1 chain B against the predicted model P23246: TM-score 0.92, RMSD 1.98 Å
- 7PU5 chain H against the predicted model P23246: TM-score 0.92, RMSD 1.83 Å
- 7UK1 chain A against the predicted model P23246: TM-score 0.91, RMSD 1.94 Å
- 4WII chain B against the predicted model P23246: TM-score 0.91, RMSD 1.89 Å
- 4WII chain B against the predicted model P23246: TM-score 0.91, RMSD 1.89 Å
Elsewhere
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