MolNFT v1 · #108803 · protein
Human splicing factor, construct 1
4WIJ · Splicing factor, proline- and glutamine-rich: “Human splicing factor, construct 1”. X-ray diffraction, 8 pockets (best druggability 0.78). MolNFT v1 #108803 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4WIJ
- Type
- protein
- Length
- 599 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Splicing factor, proline- and glutamine-rich
- UniProt
- P23246
- Pockets
- 8 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 50% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Splicing factor, proline- and glutamine-rich | protein | 298 | 51% helix, 16% strand | P23246 |
| B | Splicing factor, proline- and glutamine-rich | protein | 301 | 50% helix, 15% strand | P23246 |
Pockets
8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 812 | 0.78 | 0.82 | 59 | empty |
| 2 | 296 | 0.58 | 0.77 | 35 | empty |
| 3 | 79 | 0.49 | 0.84 | 28 | empty |
| 4 | 175 | 0.44 | 0.74 | 25 | empty |
| 5 | 141 | 0.43 | 0.76 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 4565 Ų buried · 74 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23246
- Elsewhere: RCSB PDB 4WIJ · PDBe 4WIJ · UniProt P23246
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.