MolNFT v1 · #168647 · protein
Crystal structure of human SFPQ/NONO complex
6WMZ · Splicing factor, proline- and glutamine-rich: “Crystal structure of human SFPQ/NONO complex”. X-ray diffraction, 1 ligand (SO4), 15 pockets (best druggability 0.85). MolNFT v1 #168647 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6WMZ
- Type
- protein
- Length
- 1,085 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Splicing factor, proline- and glutamine-rich; Non-pou domain-containing octamer-binding…
- UniProt
- P23246, Q15233
- Ligands
- SO4
- Pockets
- 15 · best druggability 0.85
Structure
x-ray diffraction · 4 distinct chains · 45% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Splicing factor, proline- and glutamine-rich | protein | 299 | 50% helix, 17% strand | P23246 |
| B | Non-pou domain-containing octamer-binding protein | protein | 240 | 40% helix, 23% strand | Q15233 |
| C | Splicing factor, proline- and glutamine-rich | protein | 292 | 52% helix, 16% strand | P23246 |
| D | Non-pou domain-containing octamer-binding protein | protein | 254 | 35% helix, 20% strand | Q15233 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · chains D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
15 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 970 | 0.85 | 0.86 | 97 | empty |
| 2 | 704 | 0.74 | 0.80 | 51 | empty |
| 3 | 313 | 0.68 | 0.82 | 37 | empty |
| 4 | 190 | 0.61 | 0.83 | 29 | empty |
| 5 | 264 | 0.58 | 0.78 | 27 | empty |
Interfaces
6 interfaces between chains.
- C–D · 4571 Ų buried · 75 hydrogen bonds · protein-protein
- A–B · 4524 Ų buried · 74 hydrogen bonds · protein-protein
- B–D · 677 Ų buried · 4 hydrogen bonds · protein-protein
- A–D · 320 Ų buried · 4 hydrogen bonds · protein-protein
- A–C · 164 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6WMZ · Crystal structure of human SFPQ/NONO complex · the same entry in another collection · chain D against D, TM-score 1.00
- Q15233 · AlphaFold monomer V2.0 prediction for non-pou domain-containing octamer-binding protein… · a predicted model of the same protein · chain B against A, TM-score 0.93
- P23246 · AlphaFold monomer V2.0 prediction for splicing factor, proline- and glutamine-rich… · a predicted model of the same protein · chain A against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23246
- Every structure of UniProt Q15233
- Elsewhere: RCSB PDB 6WMZ · PDBe 6WMZ · UniProt P23246 · UniProt Q15233
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