MolNFT v1 · #181334 · protein
Crystal structure of human SFPQ/NONO heterodimer, conserved dbhs region
7LRQ · Splicing factor, proline- and glutamine-rich: “Crystal structure of human SFPQ/NONO heterodimer, conserved dbhs region”. X-ray diffraction, 1 ligand (CL), 3 pockets (best druggability 0.83). MolNFT v1 #181334 on GenesisL1: 3D…
- PDB
- 7LRQ
- Type
- protein
- Length
- 486 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Splicing factor, proline- and glutamine-rich; Non-pou domain-containing octamer-binding…
- UniProt
- P23246, Q15233
- Ligands
- CL
- Pockets
- 3 · best druggability 0.83
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Splicing factor, proline- and glutamine-rich | protein | 239 | 39% helix, 23% strand | P23246 |
| B | Non-pou domain-containing octamer-binding protein | protein | 247 | 37% helix, 21% strand | Q15233 |
Ligands and binding sites
- CL · Chloride ion · ion · 5 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 939 | 0.83 | 0.85 | 81 | empty |
| 2 | 114 | 0.38 | 0.74 | 26 | empty |
| 3 | 70 | 0.32 | 0.75 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 4514 Ų buried · 67 hydrogen bonds · protein-protein
Compared structures
- 7LRQ · Crystal structure of human SFPQ/NONO heterodimer, conserved DBHS region · the same entry in another collection · chain A against A, TM-score 1.00
- Q15233 · AlphaFold monomer V2.0 prediction for non-pou domain-containing octamer-binding protein… · a predicted model of the same protein · chain B against A, TM-score 0.93
- P23246 · AlphaFold monomer V2.0 prediction for splicing factor, proline- and glutamine-rich… · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23246
- Every structure of UniProt Q15233
- Elsewhere: RCSB PDB 7LRQ · PDBe 7LRQ · UniProt P23246 · UniProt Q15233
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