MolNFT v1 · #108804 · protein

Human splicing factor, construct 2

4WIK · Splicing factor, proline- and glutamine-rich: “Human splicing factor, construct 2”. X-ray diffraction, 4 pockets (best druggability 0.59). MolNFT v1 #108804 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4WIK
Type: protein
Length: 453 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Splicing factor, proline- and glutamine-rich
UniProt: P23246
Pockets: 4 · best druggability 0.59

Structure

x-ray diffraction · 2 distinct chains · 60% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Splicing factor, proline- and glutamine-rich	protein	228	62% helix, 14% strand	P23246
B	Splicing factor, proline- and glutamine-rich	protein	225	58% helix, 15% strand	P23246

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	360	0.59	0.76	36	empty
2	301	0.54	0.75	42	empty
3	350	0.51	0.72	29	empty
4	59	0.31	0.76	13	empty

Interfaces

1 interface between chains.

A–B · 4347 Å² buried · 81 hydrogen bonds · protein-protein

Compared structures

4WIK · Human splicing factor, construct 2 · the same entry in another collection · chain A against A, TM-score 1.00
P23246 · AlphaFold monomer V2.0 prediction for splicing factor, proline- and glutamine-rich… · a predicted model of the same protein · chain B against A, TM-score 0.79

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P23246
Elsewhere: RCSB PDB 4WIK · PDBe 4WIK · UniProt P23246

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