MolNFT v1 · #185406 · protein

Structure of sfpq-nono complex

7PU5 · Non-pou domain-containing octamer-binding protein: “Structure of sfpq-nono complex”. X-ray diffraction, 1 ligand (MG), 20 pockets (best druggability 0.85). MolNFT v1 #185406 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 7PU5
Type: protein
Length: 2,871 residues
Chains: 12
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Non-pou domain-containing octamer-binding protein; Splicing factor, proline- and…
UniProt: Q15233, P23246
Ligands: MG
Pockets: 20 · best druggability 0.85

Structure

x-ray diffraction · 7 distinct chains · 40% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C	Non-pou domain-containing octamer-binding protein	protein	242	40% helix, 24% strand	Q15233
B, D, F, J	Splicing factor, proline- and glutamine-rich	protein	239	41% helix, 23% strand	P23246
E	Non-pou domain-containing octamer-binding protein	protein	237	39% helix, 24% strand	Q15233
G	Non-pou domain-containing octamer-binding protein	protein	237	39% helix, 23% strand	Q15233
H, L	Splicing factor, proline- and glutamine-rich	protein	240	42% helix, 23% strand	P23246
I	Non-pou domain-containing octamer-binding protein	protein	238	39% helix, 25% strand	Q15233
K	Non-pou domain-containing octamer-binding protein	protein	239	38% helix, 25% strand	Q15233

Ligands and binding sites

MG · Magnesium ion · metal · 12 copies · chains B, A, D, C, F, E, H, G, J, I, K, L

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 17 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	840	0.85	0.87	79	empty
2	1114	0.83	0.84	88	empty
3	1148	0.80	0.82	84	MG
4	935	0.79	0.82	68	empty
5	912	0.79	0.82	66	empty

Interfaces

17 interfaces between chains.

A–B · 4566 Å² buried · 83 hydrogen bonds · protein-protein
K–L · 4542 Å² buried · 78 hydrogen bonds · protein-protein
E–F · 4540 Å² buried · 84 hydrogen bonds · protein-protein
C–D · 4536 Å² buried · 81 hydrogen bonds · protein-protein
G–H · 4511 Å² buried · 81 hydrogen bonds · protein-protein

Compared structures

7PU5 · Structure of SFPQ-NONO complex · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q15233
Every structure of UniProt P23246
Elsewhere: RCSB PDB 7PU5 · PDBe 7PU5 · UniProt Q15233 · UniProt P23246

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