MolNFT v1 · #181338 · protein

Crystal structure of sfpq-nono-sfpq chimeric protein homodimer

7LRU · Splicing factor, proline- and glutamine-RICH,ISOFORM 2 of…: “Crystal structure of sfpq-nono-sfpq chimeric protein homodimer”. X-ray diffraction, 1 pocket (best druggability 0.42). MolNFT v1 #181338 on GenesisL1: 3D structure…

PDB: 7LRU
Type: protein
Length: 255 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Splicing factor, proline- and glutamine-RICH,ISOFORM 2 of non-pou domain-containing…
UniProt: P23246, Q15233
Pockets: 1 · best druggability 0.42

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Splicing factor, proline- and glutamine-RICH,ISOFORM 2 of non-pou domain-containing octamer-binding PROTEIN,ISOFORM short of splicing factor, proline- and glutamine-rich	protein	255	40% helix, 20% strand	P23246, Q15233

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	171	0.42	0.74	25	empty

Compared structures

7LRU · Crystal structure of SFPQ-NONO-SFPQ chimeric protein homodimer · the same entry in another collection · chain B against B, TM-score 1.00
P23246 · AlphaFold monomer V2.0 prediction for splicing factor, proline- and glutamine-rich… · a predicted model of the same protein · chain B against A, TM-score 0.92
Q15233 · AlphaFold monomer V2.0 prediction for non-pou domain-containing octamer-binding protein… · a predicted model of the same protein · chain B against A, TM-score 0.90

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P23246
Every structure of UniProt Q15233
Elsewhere: RCSB PDB 7LRU · PDBe 7LRU · UniProt P23246 · UniProt Q15233

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