UniProt P22756
Glutamate receptor ionotropic, kainate 1,Glutamate receptor ionotropic, kainate 1 (P22756)
Glutamate receptor ionotropic, kainate 1,Glutamate receptor ionotropic, kainate 1 (UniProt P22756): 69 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 12 pockets. Binding sites, druggability and…
- UniProt
- P22756
- Protein
- Glutamate receptor ionotropic, kainate 1,Glutamate receptor ionotropic, kainate…
- Experimental structures
- 69
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 12 · 3 records with a druggable one
Structures
70 records of P22756 in the MolNFT archive: 69 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1TXF | Crystal structure of the GLUR5 ligand binding core in complex with glutamate at 2.1 ångström… | x-ray diffraction | A | — | — |
| 1TXF | Crystal structure of the GLUR5 ligand binding core in complex with glutamate at 2.1 ångström… | x-ray diffraction | A | — | — |
| 1VSO | Crystal Structure of the Ligand-Binding Core of iGluR5 in Complex With the Antagonist (S)-ATPO at… | x-ray diffraction | A | — | — |
| 1VSO | Crystal structure of the ligand-binding core of IGLUR5 in complex with the antagonist (S)-atpo at… | x-ray diffraction | A | — | — |
| 1YCJ | Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate | x-ray diffraction | A, B | — | — |
| 1YCJ | Crystal structure of the kainate receptor GLUR5 ligand-binding core in complex with (S)-glutamate | x-ray diffraction | A, B | — | — |
| 2F34 | Crystal Structure of the GluR5 Ligand Binding Core Dimer with UBP310 At 1.74 Angstroms Resolution | x-ray diffraction | A, B | — | — |
| 2F34 | Crystal structure of the GLUR5 ligand binding core dimer with UBP310 at 1.74 ångströms resolution | x-ray diffraction | A, B | — | — |
| 2F35 | Crystal Structure of the GluR5 Ligand Binding Core with UBP302 At 1.87 Angstroms Resolution | x-ray diffraction | A, B | — | — |
| 2F35 | Crystal structure of the GLUR5 ligand binding core with UBP302 at 1.87 ångströms resolution | x-ray diffraction | A, B | — | — |
| 2F36 | Crystal Structure of the GluR5 Ligand Binding Core Dimer with Glutamate At 2.1 Angstroms Resolution | x-ray diffraction | A, B, C, D | — | — |
| 2F36 | Crystal structure of the GLUR5 ligand binding core dimer with glutamate at 2.1 ångströms resolution | x-ray diffraction | A, B, C, D | — | — |
| 2OJT | Structure and mechanism of kainate receptor modulation by anions | x-ray diffraction | A, B | — | — |
| 2OJT | Structure and mechanism of kainate receptor modulation by anions | x-ray diffraction | A, B | — | — |
| 2PBW | Crystal Structure of the Ligand-Binding Core of iGluR5 in Complex with the Partial agonist Domoic… | x-ray diffraction | A, B | — | — |
| 2PBW | Crystal structure of the ligand-binding core of IGLUR5 in complex with the partial agonist domoic… | x-ray diffraction | A, B | — | — |
| 2QS1 | Crystal structure of the GluR5 ligand binding core dimer in complex with UBP315 at 1.80 Angstroms… | x-ray diffraction | A, B | — | — |
| 2QS1 | Crystal structure of the GLUR5 ligand binding core dimer in complex with UBP315 at 1.80 ångströms… | x-ray diffraction | A, B | — | — |
| 2QS2 | Crystal structure of the GluR5 ligand binding core dimer in complex with UBP318 at 1.80 Angstroms… | x-ray diffraction | A, B | — | — |
| 2QS2 | Crystal structure of the GLUR5 ligand binding core dimer in complex with UBP318 at 1.80 ångströms… | x-ray diffraction | A, B | — | — |
| 2QS3 | Crystal structure of the GluR5 ligand binding core dimer in complex with UBP316 at 1.76 Angstroms… | x-ray diffraction | A, B | — | — |
| 2QS3 | Crystal structure of the GLUR5 ligand binding core dimer in complex with UBP316 at 1.76 ångströms… | x-ray diffraction | A, B | — | — |
| 2QS4 | Crystal structure of the GluR5 ligand binding core dimer in complex with LY466195 at 1.58 Angstroms… | x-ray diffraction | A, B, C, D | — | — |
| 2QS4 | Crystal structure of the GLUR5 ligand binding core dimer in complex with LY466195 at 1.58 ångströms… | x-ray diffraction | A, B, C, D | — | — |
| 2WKY | Crystal structure of the ligand-binding core of GluR5 in complex with the agonist 4-AHCP | x-ray diffraction | A, B | — | — |
| 2WKY | Crystal structure of the ligand-binding core of GLUR5 in complex with the agonist 4-ahcp | x-ray diffraction | A, B | — | — |
| 3C31 | Crystal structure of GluR5 ligand-binding core in complex with lithium at 1.49 Angstrom resolution | x-ray diffraction | A, B | — | — |
| 3C31 | Crystal structure of GLUR5 ligand-binding core in complex with lithium at 1.49 ångström resolution | x-ray diffraction | A, B | — | — |
| 3C32 | Crystal structure of GluR5 ligand-binding core in complex with sodium at 1.72 Angstrom resolution | x-ray diffraction | A, B | — | — |
| 3C32 | Crystal structure of GLUR5 ligand-binding core in complex with sodium at 1.72 ångström resolution | x-ray diffraction | A, B | — | — |
| 3C33 | Crystal structure of GluR5 ligand-binding core in complex with potassium at 1.78 Angstrom resolution | x-ray diffraction | A, B | — | — |
| 3C33 | Crystal structure of GLUR5 ligand-binding core in complex with potassium at 1.78 ångström resolution | x-ray diffraction | A, B | — | — |
| 3C34 | Crystal structure of GluR5 ligand-binding core in complex with rubidium at 1.82 Angstrom resolution | x-ray diffraction | A, B | — | — |
| 3C34 | Crystal structure of GLUR5 ligand-binding core in complex with rubidium at 1.82 ångström resolution | x-ray diffraction | A, B | — | — |
| 3C35 | Crystal structure of GluR5 ligand-binding core in complex with cesium at 1.97 Angstrom resolution | x-ray diffraction | A, B | — | — |
| 3C35 | Crystal structure of GLUR5 ligand-binding core in complex with cesium at 1.97 ångström resolution | x-ray diffraction | A, B | — | — |
| 3C36 | Crystal structure of GluR5 ligand-binding core in complex with ammonium ions at 1.68 Angstrom… | x-ray diffraction | A, B | — | — |
| 3C36 | Crystal structure of GLUR5 ligand-binding core in complex with ammonium ions at 1.68 ångström… | x-ray diffraction | A, B | — | — |
| 3GBA | X-ray structure of iGluR5 ligand-binding core (S1S2) in complex with dysiherbaine at 1.35A… | x-ray diffraction | A, B, C, D | — | — |
| 3GBA | X-ray structure of IGLUR5 ligand-binding core (S1S2) in complex with dysiherbaine at 1.35A… | x-ray diffraction | A, B, C, D | — | — |
| 3GBB | X-ray structure of iGluR5 ligand-binding core (S1S2) in complex with MSVIII-19 at 2.10A resolution | x-ray diffraction | A, B | — | — |
| 3GBB | X-ray structure of IGLUR5 ligand-binding core (S1S2) in complex with msviii-19 at 2.10A resolution | x-ray diffraction | A, B | — | — |
| 3S2V | Crystal Structure of the Ligand Binding Domain of GluK1 in Complex with an Antagonist… | x-ray diffraction | A, B | — | — |
| 3S2V | Crystal structure of the ligand binding domain of GLUK1 in complex with an antagonist… | x-ray diffraction | A, B | — | — |
| 4DLD | Crystal structure of the GluK1 ligand-binding domain (S1S2) in complex with the antagonist… | x-ray diffraction | A, B | — | — |
| 4DLD | Crystal structure of the GLUK1 ligand-binding domain (S1S2) in complex with the antagonist… | x-ray diffraction | A, B | — | — |
| 4E0X | Crystal structure of the kainate receptor GluK1 ligand-binding domain in complex with kainate in… | x-ray diffraction | A, B | — | — |
| 4E0X | Crystal structure of the kainate receptor GLUK1 ligand-binding domain in complex with kainate in… | x-ray diffraction | A, B | — | — |
| 4QF9 | Structure of GluK1 ligand-binding domain (S1S2) in complex with… | x-ray diffraction | A, B, C | — | — |
| 4QF9 | Structure of GLUK1 ligand-binding domain (S1S2) in complex with (S)-2… | x-ray diffraction | A, B, C | — | — |
| 4YMB | Structure of the ligand-binding domain of GluK1 in complex with the antagonist CNG10111 | x-ray diffraction | A, B | — | — |
| 4YMB | Structure of the ligand-binding domain of GLUK1 in complex with the antagonist CNG10111 | x-ray diffraction | A, B | — | — |
| 5M2V | Structure of GluK1 ligand-binding domain (S1S2) in complex with… | x-ray diffraction | A, B | 7E5, SO4, CL | — |
| 5M2V | Structure of GLUK1 ligand-binding domain (S1S2) in complex with (2S… | x-ray diffraction | A, B | 7E5, SO4, CL | — |
| 5MFQ | Crystal structure of the GluK1 ligand-binding domain in complex with kainate and BPAM-344 at 1.90 A… | x-ray diffraction | A, B | 2J9, KAI, CL, SO4 | 6 (best 0.75) |
| 5MFQ | Crystal structure of the GLUK1 ligand-binding domain in complex with kainate and bpam-344 at 1.90 a… | x-ray diffraction | A, B | 2J9, CL | — |
| 5MFV | Crystal structure of the GluK1 ligand-binding domain in complex with kainate and BPAM-521 at 2.18 A… | x-ray diffraction | A, B | 5PX, CL, SO4 | — |
| 5MFV | Crystal structure of the GLUK1 ligand-binding domain in complex with kainate and bpam-521 at 2.18 a… | x-ray diffraction | A, B | 5PX, CL, SO4 | — |
| 5MFW | Crystal structure of the GluK1 ligand-binding domain in complex with kainate and BPAM-121 at 2.10 A… | x-ray diffraction | A, B | 7M6, CL, SO4 | — |
| 5MFW | Crystal structure of the GLUK1 ligand-binding domain in complex with kainate and bpam-121 at 2.10 a… | x-ray diffraction | A, B | 7M6, CL, SO4 | — |
10 records more on the page itself.
Ligands
- CL · Chloride ion · in 16 records
- SO4 · Sulfate ion · in 15 records
- 2J9 · 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide · in 2 records
- 5PX · 4-Cyclopropyl-3,4-dihydro-7-hydroxy-2H-1,2,4-benzothiadiazine 1,1-dioxide · in 2 records
- 7E5 · (2~{S},4~{R})-4-(2-carboxyphenoxy)pyrrolidine-2-carboxylic acid · in 2 records
- 7M6 · 7-chloro-4-(2-fluoroethyl)-2,3-dihydro-1,2,4-benzothiadiazine 1,1-dioxide · in 2 records
- 8VE · (3~{a}~{R},4~{S},6~{a}~{R})-1-methyl-4,5,6,6~{a}-tetrahydro-3~{a}~{H}-pyrrolo[3,4-c]pyrazole-3,4-dicarboxylic acid · in 2 records
- 8VN · (3~{a}~{S},4~{S},6~{a}~{R})-4,5,6,6~{a}-tetrahydro-3~{a}~{H}-pyrrolo[3,4-d][1,2]oxazole-3,4-dicarboxylic acid · in 2 records
- EC8 · N-(7-fluoro-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl)-2-hydroxybenzamide · in 2 records
- L5H · ~{N}-[7-imidazol-1-yl-2,3-bis(oxidanylidene)-6-(trifluoromethyl)-4~{H}-quinoxalin-1-yl]benzamide · in 2 records
- KAI · 3-(carboxymethyl)-4-isopropenylproline · in 1 record
Experiment against prediction
- 5MFQ chain A against the predicted model P22756: TM-score 0.98, RMSD 0.79 Å
- 5NF5 chain A against the predicted model P22756: TM-score 0.98, RMSD 0.80 Å
- 4DLD chain B against the predicted model P22756: TM-score 0.98, RMSD 0.82 Å
- 4DLD chain B against the predicted model P22756: TM-score 0.98, RMSD 0.82 Å
- 2WKY chain B against the predicted model P22756: TM-score 0.98, RMSD 0.82 Å
- 2WKY chain B against the predicted model P22756: TM-score 0.98, RMSD 0.82 Å
- 2PBW chain A against the predicted model P22756: TM-score 0.98, RMSD 0.73 Å
- 2PBW chain A against the predicted model P22756: TM-score 0.98, RMSD 0.73 Å
- 4DLD chain A against the predicted model P22756: TM-score 0.98, RMSD 0.86 Å
- 4DLD chain A against the predicted model P22756: TM-score 0.98, RMSD 0.86 Å
Elsewhere
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