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Ligand · DYH

DYH · (2R,3aR,6S,7R,7aR)-2-[(2S)-2-amino-2-carboxyethyl]-6-hydroxy-7-(methylamino)hexahydro-2H-furo[3,2-b]pyran-2-carboxylic acid

DYH, (2R,3aR,6S,7R,7aR)-2-[(2S)-2-amino-2-carboxyethyl]-6-hydroxy-7-(methylamino)hexahydro-2H-furo[3,2-b]pyran-2-carboxylic acid (C12 H20 N2 O7, 304.3 g/mol), in the MolNFT structures on GenesisL1: bound in 6 records (3 PDB entries). Every…

Component
DYH
Formula
C12 H20 N2 O7
Class
ligand
Structures
6
PDB entries
3

Binding sites

DYH in 6 structures; the first of them:

  • 2ZNT · Crystal structure of the ligand-binding core of the human ionotropic glutamate receptor… · DYH A1 · binds GLU426, TYR429, TYR474, PRO501, LEU502, THR503, ARG508, VAL670 and 9 more
  • 3FV1 · Crystal Structure of the human glutamate receptor, GluR5, ligand-binding core in complex… · DYH A1 · binds GLU426, TYR429, TYR474, PRO501, LEU502, THR503, ARG508, VAL670 and 8 more
  • 3GBA · X-ray structure of iGluR5 ligand-binding core (S1S2) in complex with dysiherbaine at… · DYH A258 · binds GLU13, TYR16, TYR61, PRO88, LEU89, THR90, ARG95, VAL137 and 8 more
  • 2ZNT · Crystal structure of the ligand-binding core of the human ionotropic glutamate receptor… · DYH A1 · binds GLU426, TYR429, TYR474, PRO501, LEU502, THR503, ARG508, VAL670 and 9 more
  • 3FV1 · Crystal structure of the human glutamate receptor, GLUR5, ligand- binding core in complex… · DYH A1 · binds GLU426, TYR429, TYR474, PRO501, LEU502, THR503, ARG508, VAL670 and 8 more
  • 3GBA · X-ray structure of IGLUR5 ligand-binding core (S1S2) in complex with dysiherbaine at… · DYH A258 · binds GLU13, TYR16, TYR61, PRO88, LEU89, THR90, ARG95, VAL137 and 8 more

Residues it binds most

SER 14, TYR 14, GLU 14, THR 14, MET 14, ARG 14, GLY 14, LEU 14, PRO 14, VAL 14 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion
  • GOL · Glycerol
  • CL · Chloride ion
  • BME · Beta-mercaptoethanol

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