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Ligand · AT1

AT1 · (S)-2-amino-3-(5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl)propionic acid

AT1, (S)-2-amino-3-(5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl)propionic acid (C11 H19 N2 O7 P, 322.2 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within 4.5 Å…

Component
AT1
Formula
C11 H19 N2 O7 P
Class
ligand
Structures
4
PDB entries
2

Binding sites

AT1 in 4 structures; the first of them:

  • 1N0T · X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with the antagonist… · AT1 A264 · binds GLU13, TYR61, PRO89, LEU90, THR91, ARG96, LEU138, SER140 and 8 more
  • 1VSO · Crystal Structure of the Ligand-Binding Core of iGluR5 in Complex With the Antagonist… · AT1 A258 · binds GLU13, TYR16, TYR61, PRO88, LEU89, THR90, ARG95, GLY140 and 6 more
  • 1N0T · X-ray structure of the GLUR2 ligand-binding core (S1S2J) in complex with the antagonist… · AT1 A264 · binds GLU13, TYR61, PRO89, LEU90, THR91, ARG96, LEU138, SER140 and 8 more
  • 1VSO · Crystal structure of the ligand-binding core of IGLUR5 in complex with the antagonist… · AT1 A258 · binds GLU13, TYR16, TYR61, PRO88, LEU89, THR90, ARG95, GLY140 and 6 more

Residues it binds most

THR 10, TYR 10, GLU 10, SER 10, LEU 10, ARG 10, GLY 10, PRO 10, MET 8 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion
  • ACT · Acetate ion
  • GOL · Glycerol

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