MolNFT v1 · #25473 · protein
Crystal structure of the ligand-binding core of IGLUR5 in complex with the antagonist (S)-atpo at 1.85 a resolution
1VSO · Glutamate receptor, ionotropic kainate 1: “Crystal structure of the ligand-binding core of IGLUR5 in complex with the antagonist (S)-atpo at 1.85 a…”. X-ray diffraction, 1 ligand (AT1), 1 pocket (best druggability 0.58). MolNFT v1…
- PDB
- 1VSO
- Type
- protein
- Length
- 243 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate receptor, ionotropic kainate 1
- UniProt
- P22756
- Ligands
- AT1
- Pockets
- 1 · best druggability 0.58
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutamate receptor, ionotropic kainate 1 | protein | 243 | 38% helix, 21% strand | P22756 |
Ligands and binding sites
- AT1 · (S)-2-amino-3-(5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl)propionic acid · ligand · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 380 | 0.58 | 0.76 | 40 | AT1, GOL |
Compared structures
- 1VSO · Crystal Structure of the Ligand-Binding Core of iGluR5 in Complex With the Antagonist… · the same entry in another collection · chain A against A, TM-score 1.00
- P22756 · AlphaFold monomer V2.0 prediction for glutamate receptor ionotropic, kainate 1 (P22756) · a predicted model of the same protein · chain A against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22756
- Elsewhere: RCSB PDB 1VSO · PDBe 1VSO · UniProt P22756
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