UniProt P21447
ATP-dependent translocase ABCB1 (P21447)
ATP-dependent translocase ABCB1 (UniProt P21447), EC 3.6.3.44, 7.6.2.1: 55 experimental structures on GenesisL1, 9 ligands bound, 113 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P21447
- Protein
- ATP-dependent translocase ABCB1
- EC
- 3.6.3.44, 7.6.2.1, 7.6.2.2
- Experimental structures
- 55
- Predicted models
- 0
- Ligands
- 9
- Pockets
- 113 · 8 records with a druggable one
Structures
55 records of P21447 in the MolNFT archive: 55 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4KSB | Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the… | x-ray diffraction | A | — | — |
| 4KSB | Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the… | x-ray diffraction | A | — | — |
| 4KSC | Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the… | x-ray diffraction | A | — | — |
| 4KSC | Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the… | x-ray diffraction | A | — | — |
| 4KSD | Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the… | x-ray diffraction | A | — | — |
| 4KSD | Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the… | x-ray diffraction | A | — | — |
| 4LSG | Structure of Mouse P-Glycoprotein | x-ray diffraction | A, B | — | — |
| 4LSG | Structure of mouse P-glycoprotein | x-ray diffraction | A, B | — | — |
| 4M1M | Corrected Structure of Mouse P-glycoprotein | x-ray diffraction | A, B | — | — |
| 4M1M | Corrected structure of mouse P-glycoprotein | x-ray diffraction | A, B | — | — |
| 4M2S | Corrected Structure of Mouse P-glycoprotein bound to QZ59-RRR | x-ray diffraction | A, B | — | — |
| 4M2S | Corrected structure of mouse P-glycoprotein bound to QZ59-rrr | x-ray diffraction | A, B | — | — |
| 4M2T | Corrected Structure of Mouse P-glycoprotein bound to QZ59-SSS | x-ray diffraction | A, B | — | — |
| 4M2T | Corrected structure of mouse P-glycoprotein bound to QZ59-sss | x-ray diffraction | A, B | — | — |
| 4Q9H | P-glycoprotein at 3.4 A resolution | x-ray diffraction | A | — | — |
| 4Q9H | P-glycoprotein at 3.4 a resolution | x-ray diffraction | A | — | — |
| 4Q9I | P-glycoprotein cocrystallised with QZ-Ala | x-ray diffraction | A | — | — |
| 4Q9I | P-glycoprotein cocrystallised with qz-ala | x-ray diffraction | A | — | — |
| 4Q9J | P-glycoprotein cocrystallised with QZ-Val | x-ray diffraction | A | — | — |
| 4Q9J | P-glycoprotein cocrystallised with qz-val | x-ray diffraction | A | — | — |
| 4Q9K | P-glycoprotein cocrystallised with QZ-Leu | x-ray diffraction | A | — | — |
| 4Q9K | P-glycoprotein cocrystallised with qz-leu | x-ray diffraction | A | — | — |
| 4Q9L | P-glycoprotein cocrystallised with QZ-Phe | x-ray diffraction | A | — | — |
| 4Q9L | P-glycoprotein cocrystallised with qz-phe | x-ray diffraction | A | — | — |
| 4XWK | P-glycoprotein co-crystallized with BDE-100 | x-ray diffraction | A | — | — |
| 4XWK | P-glycoprotein co-crystallized with bde-100 | x-ray diffraction | A | — | — |
| 5KO2 | Mouse pgp 34 linker deleted mutant Hg derivative | x-ray diffraction | A, B | HG | — |
| 5KO2 | Mouse pgp 34 linker deleted mutant hg derivative | x-ray diffraction | A, B | HG | — |
| 5KOY | Mouse pgp 34 linker deleted bound with ATP | x-ray diffraction | A, B | ATP | — |
| 5KOY | Mouse pgp 34 linker deleted bound with ATP | x-ray diffraction | A, B | ATP | — |
| 5KPD | Mouse pgp 34 linker deleted double eq mutant | x-ray diffraction | A, B | — | — |
| 5KPI | Mouse native PGP | x-ray diffraction | A, B | — | — |
| 5KPI | Mouse native pgp | x-ray diffraction | A, B | — | — |
| 5KPJ | Mouse pgp methylated protein | x-ray diffraction | A | — | — |
| 5KPJ | Mouse pgp methylated protein | x-ray diffraction | A | — | — |
| 6GDI | Structure of P-GLYCOPROTEIN(ABCB1) in the post-hydrolytic state | electron microscopy | A | — | — |
| 6Q81 | Structure of P-glycoprotein(ABCB1) in the post-hydrolytic state | electron microscopy | A | ADP | 18 (best 0.82) |
| 6Q81 | Structure of P-GLYCOPROTEIN(ABCB1) in the post-hydrolytic state | electron microscopy | A | ADP | — |
| 6UJN | P-glycoprotein mutant-C952A-with BDE100 | x-ray diffraction | A | 4C8 | 11 (best 0.82) |
| 6UJN | P-glycoprotein mutant-C952A-with BDE100 | x-ray diffraction | A | 4C8 | — |
| 6UJP | P-glycoprotein mutant-F979A and C952A-with BDE100 | x-ray diffraction | A | 4C8 | — |
| 6UJR | P-glycoprotein mutant-F724A and C952A-with BDE100 | x-ray diffraction | A | 4C8 | — |
| 6UJR | P-glycoprotein mutant-F724A and C952A-with BDE100 | x-ray diffraction | A | 4C8 | — |
| 6UJS | P-glycoprotein mutant-F728A and C952A-with BDE100 | x-ray diffraction | A | 4C8 | 13 (best 0.82) |
| 6UJS | P-glycoprotein mutant-F728A and C952A-with BDE100 | x-ray diffraction | A | 4C8 | — |
| 6UJT | P-glycoprotein mutant-Y303A and C952A-with BDE100 | x-ray diffraction | A | 4C8 | — |
| 6UJW | P-glycoprotein mutant-Y306A and C952A-with BDE100 | x-ray diffraction | A | 4C8 | 12 (best 0.80) |
| 6UJW | P-glycoprotein mutant-Y306A and C952A-with BDE100 | x-ray diffraction | A | 4C8 | — |
| 7OTG | Structure of ABCB1/P-glycoprotein in the presence of the CFTR potentiator ivacaftor | electron microscopy | A | VX7 | 11 (best 0.84) |
| 7OTG | Structure of ABCB1/P-glycoprotein in the presence of the cftr potentiator ivacaftor | electron microscopy | A | VX7 | — |
| 7OTI | Structure of ABCB1/P-glycoprotein in apo state | electron microscopy | A | — | — |
| 7ZK5 | ABCB1 L335C mutant (mABCB1) in the outward facing state bound to AAC | electron microscopy | A | ATP, MG, Y01, JIZ | 18 (best 0.86) |
| 8AVY | The ABCB1 L335C mutant (mABCB1) in the Apo state | electron microscopy | A | ATP, MG, Y01 | 13 (best 0.90) |
| 8PEE | ABCB1 L335C mutant (mABCB1) in the inward facing state bound to AAC | electron microscopy | A | JJI, JIZ, Y01 | 17 (best 0.82) |
| P21447 | AlphaFold monomer V2.0 prediction for ATP-dependent translocase ABCB1 (P21447) | — | — | — |
Ligands
- 4C8 · 2,4-dibromophenyl 2,4,6-tribromophenyl ether · in 10 records
- ATP · Adenosine-5'-triphosphate · in 4 records
- Y01 · Cholesterol hemisuccinate · in 3 records
- ADP · Adenosine-5'-diphosphate · in 2 records
- HG · Mercury (II) ion · in 2 records
- JIZ · (4~{S},11~{S},18~{S})-4,11-dimethyl-18-(sulfanylmethyl)-6,13,20-trithia-3,10,17,22,23,24-hexazatetracyclo[17.2.1.1^{5,8}.1^{12,15}]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione · in 2 records
- MG · Magnesium ion · in 2 records
- VX7 · N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide · in 2 records
- JJI · (4S,11S,18S)-4-[[(2,4-dinitrophenyl)disulfanyl]methyl]-11,18-dimethyl-6,13,20-trithia-3,10,17,22,23,24-hexazatetracyclo[17.2.1.1^{5,8}.1^{12,15}]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione · in 1 record
Elsewhere
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