MolNFT v1 · #97884 · protein
Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain
4KSB · Multidrug resistance protein 1A: “Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding…”. X-ray diffraction, 19 pockets (best druggability 0.79). MolNFT v1 #97884 on GenesisL1…
- PDB
- 4KSB
- Type
- protein
- Length
- 1,182 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Multidrug resistance protein 1A
- EC
- 3.6.3.44
- UniProt
- P21447
- Pockets
- 19 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 61% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Multidrug resistance protein 1A (EC 3.6.3.44) | protein | 1182 | 61% helix, 8% strand | P21447 |
Pockets
19 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 540 | 0.79 | 0.85 | 84 | empty |
| 2 | 358 | 0.71 | 0.83 | 51 | empty |
| 3 | 340 | 0.70 | 0.83 | 42 | empty |
| 4 | 305 | 0.70 | 0.83 | 44 | empty |
| 5 | 98 | 0.63 | 0.88 | 28 | empty |
Compared structures
- 4KSB · Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21447
- Elsewhere: RCSB PDB 4KSB · PDBe 4KSB · UniProt P21447
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