MolNFT v1 · #149891 · protein
Structure of P-GLYCOPROTEIN(ABCB1) in the post-hydrolytic state
6GDI · Multidrug resistance protein 1A: “Structure of P-GLYCOPROTEIN(ABCB1) in the post-hydrolytic state”. Electron microscopy, 16 pockets (best druggability 0.80). MolNFT v1 #149891 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6GDI
- Type
- protein
- Length
- 1,182 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Multidrug resistance protein 1A
- EC
- 3.6.3.44
- UniProt
- P21447
- Pockets
- 16 · best druggability 0.80
Structure
electron microscopy · 1 distinct chain · 61% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Multidrug resistance protein 1A (EC 3.6.3.44) | protein | 1182 | 61% helix, 8% strand | P21447 |
Pockets
16 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 984 | 0.80 | 0.81 | 77 | empty |
| 2 | 154 | 0.75 | 0.92 | 41 | empty |
| 3 | 51 | 0.68 | 0.97 | 14 | empty |
| 4 | 179 | 0.66 | 0.86 | 22 | empty |
| 5 | 379 | 0.64 | 0.79 | 55 | empty |
Compared structures
- 6GDI · Structure of P-glycoprotein(ABCB1) in the post-hydrolytic state · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21447
- Elsewhere: RCSB PDB 6GDI · PDBe 6GDI · UniProt P21447
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