MolNFT v1 · #124787 · protein
Mouse native pgp
5KPI · Multidrug resistance protein 1A: “Mouse native pgp”. X-ray diffraction, 20 pockets (best druggability 0.84). MolNFT v1 #124787 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5KPI
- Type
- protein
- Length
- 2,369 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Multidrug resistance protein 1A
- EC
- 3.6.3.44
- UniProt
- P21447
- Pockets
- 20 · best druggability 0.84
Structure
x-ray diffraction · 2 distinct chains · 64% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Multidrug resistance protein 1A (EC 3.6.3.44) | protein | 1185 | 64% helix, 10% strand | P21447 |
| B | Multidrug resistance protein 1A (EC 3.6.3.44) | protein | 1184 | 64% helix, 10% strand | P21447 |
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1035 | 0.84 | 0.84 | 101 | empty |
| 2 | 1061 | 0.84 | 0.84 | 109 | empty |
| 3 | 348 | 0.75 | 0.86 | 34 | empty |
| 4 | 731 | 0.74 | 0.80 | 63 | empty |
| 5 | 379 | 0.74 | 0.85 | 39 | empty |
Interfaces
1 interface between chains.
- A–B · 1642 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 5KPI · Mouse native PGP · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21447
- Elsewhere: RCSB PDB 5KPI · PDBe 5KPI · UniProt P21447
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.