MolNFT v1 · #124782 · protein

Mouse pgp 34 linker deleted double eq mutant

5KPD · Multidrug resistance protein 1A: “Mouse pgp 34 linker deleted double eq mutant”. X-ray diffraction, 20 pockets (best druggability 0.83). MolNFT v1 #124782 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5KPD
Type: protein
Length: 2,369 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Multidrug resistance protein 1A
EC: 3.6.3.44
UniProt: P21447
Pockets: 20 · best druggability 0.83

Structure

x-ray diffraction · 2 distinct chains · 64% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Multidrug resistance protein 1A (EC 3.6.3.44)	protein	1185	64% helix, 10% strand	P21447
B	Multidrug resistance protein 1A (EC 3.6.3.44)	protein	1184	64% helix, 10% strand	P21447

Pockets

20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	960	0.83	0.84	101	empty
2	1004	0.83	0.83	87	empty
3	333	0.75	0.86	36	empty
4	842	0.75	0.79	71	empty
5	401	0.74	0.84	38	empty

Interfaces

1 interface between chains.

A–B · 1613 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

5KPD · Mouse pgp 34 linker deleted double EQ mutant · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P21447
Elsewhere: RCSB PDB 5KPD · PDBe 5KPD · UniProt P21447

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